8BJI

chimera of ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo fused to a proline-Rich-Domain (PRD) and profilin, bound to ADP-Mg-actin and a sulfate ion

Summary for 8BJI

Entry DOI	10.2210/pdb8bji/pdb
Related	7PQJ 7PSB 7Q9D
Descriptor	Actin, alpha skeletal muscle, intermediate form, Putative Adenylate cyclase,Profilin-1, ADENOSINE-5'-DIPHOSPHATE, ... (10 entities in total)
Functional Keywords	bacterial nucleotidyl cyclase toxin, activated complex, toxin
Biological source	Vibrio nigripulchritudo More
Total number of polymer chains	2
Total formula weight	109136.28
Authors	Teixeira-Nunes, M.,Renault, L.,Retailleau, P. (deposition date: 2022-11-04, release date: 2023-09-20, Last modification date: 2023-10-04)
Primary citation	Teixeira-Nunes, M.,Retailleau, P.,Raoux-Barbot, D.,Comisso, M.,Missinou, A.A.,Velours, C.,Plancqueel, S.,Ladant, D.,Mechold, U.,Renault, L. Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19:e1011654-e1011654, 2023 Cited by PubMed: 37747912 DOI: 10.1371/journal.ppat.1011654 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation