PDB: 347 resultsInfo pagesStatus searchChemie searchBIRD

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3WF7	Crystal structure of S6K1 kinase domain in complex with a purine derivative 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide Descriptor: 1-(9H-purin-6-yl)-N-[3-(trifluoromethyl)phenyl]piperidine-4-carboxamide, GLYCEROL, Ribosomal protein S6 kinase beta-1, ... Authors: Niwa, H, Shirouzu, M, Yokoyama, S. Deposit date: 2013-07-17 Release date: 2014-08-06 Last modified: 2014-10-29 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structures of the S6K1 kinase domain in complexes with inhibitors J.Struct.Funct.Genom., 15, 2014
3WF5	Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-benzimidazol-2-yl)piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine Descriptor: 4-[4-(1H-benzimidazol-2-yl)piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine, Ribosomal protein S6 kinase beta-1, ZINC ION Authors: Niwa, H, Shirouzu, M, Yokoyama, S. Deposit date: 2013-07-17 Release date: 2014-08-06 Last modified: 2014-10-29 Method: X-RAY DIFFRACTION (2.099 Å) Cite: Crystal structures of the S6K1 kinase domain in complexes with inhibitors J.Struct.Funct.Genom., 15, 2014
3WF8	Crystal structure of S6K1 kinase domain in complex with a quinoline derivative 2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline-11-carboxylate Descriptor: 2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline-11-carboxylate, GLYCEROL, Ribosomal protein S6 kinase beta-1, ... Authors: Niwa, H, Shirouzu, M, Yokoyama, S. Deposit date: 2013-07-17 Release date: 2014-08-06 Last modified: 2014-10-29 Method: X-RAY DIFFRACTION (1.975 Å) Cite: Crystal structures of the S6K1 kinase domain in complexes with inhibitors J.Struct.Funct.Genom., 15, 2014
8DKE	Cryo-EM structure of cystinosin in a cytosol-open state Descriptor: Fab 3H5 Heavy chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin Authors: Schmiege, P, Li, X. Deposit date: 2022-07-05 Release date: 2022-09-21 Last modified: 2022-10-12 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKW	Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH5.0 Descriptor: Fab 3H5 Heavy Chain, Fab 3H5 Kappa Chain, Isoform 2 of Cystinosin Authors: Schmiege, P, Li, X. Deposit date: 2022-07-06 Release date: 2022-09-21 Last modified: 2022-10-12 Method: ELECTRON MICROSCOPY (3.09 Å) Cite: Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKI	Cryo-EM structure of cystinosin in a lumen-open state Descriptor: Fab 3H5 Heavy Chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin Authors: Schmiege, P, Li, X. Deposit date: 2022-07-05 Release date: 2022-09-21 Last modified: 2022-10-12 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKX	Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH7.5 Descriptor: Fab 3H5 Heavy Chain, Fab 3H5 Kappa Chain, Isoform 2 of Cystinosin Authors: Schmiege, P, Li, X. Deposit date: 2022-07-06 Release date: 2022-09-21 Last modified: 2022-10-12 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DKM	Cryo-EM structure of cystine-bound cystinosin in a lumen-open state Descriptor: Fab 3H5 Heavy Chain, Fab 3H5 Kappa chain, Isoform 2 of Cystinosin, ... Authors: Schmiege, P, Li, X. Deposit date: 2022-07-05 Release date: 2022-09-21 Last modified: 2022-10-12 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8DYP	Crystal structure of human cystine transporter cystinosin Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Cystinosin, Nanobody P10, ... Authors: Guo, X, Feng, L. Deposit date: 2022-08-04 Release date: 2022-11-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structure and mechanism of human cystine exporter cystinosin. Cell, 185, 2022
8FNY	Nucleotide-bound structure of a functional construct of eukaryotic elongation factor 2 kinase. Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... Authors: Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. Deposit date: 2022-12-28 Release date: 2023-05-03 Method: X-RAY DIFFRACTION (2.22 Å) Cite: ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin. Proc.Natl.Acad.Sci.USA, 120, 2023
8FO6	Nucleotide-free structure of a functional construct of eukaryotic elongation factor 2 kinase. Descriptor: CALCIUM ION, Calmodulin-1, Eukaryotic elongation factor 2 kinase, ... Authors: Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. Deposit date: 2022-12-29 Release date: 2023-05-03 Method: X-RAY DIFFRACTION (2.553 Å) Cite: ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin. Proc.Natl.Acad.Sci.USA, 120, 2023
4EKL	Akt1 with GDC0068 Descriptor: (2S)-2-(4-chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one, RAC-alpha serine/threonine-protein kinase Authors: Wu, W.-I, Vigers, G.P.A, Morales, T.H, Brandhuber, B.J. Deposit date: 2012-04-09 Release date: 2012-05-23 Last modified: 2018-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt. Sci.Signal., 5, 2012
4EKK	Akt1 with AMP-PNP Descriptor: Glycogen synthase kinase-3 beta, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Wu, W.-I, Vigers, G.P.A, Morales, T.H, Brandhuber, B.J. Deposit date: 2012-04-09 Release date: 2012-05-23 Last modified: 2018-01-24 Method: X-RAY DIFFRACTION (2.8 Å) Cite: An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt. Sci.Signal., 5, 2012
4GV1	PKB alpha in complex with AZD5363 Descriptor: 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, GLYCEROL, RAC-alpha serine/threonine-protein kinase Authors: Addie, M, Ballard, P, Bird, G, Buttar, D, Currie, G, Davies, B, Debreczeni, J, Dry, H, Dudley, P, Greenwood, R, Hatter, G, Jestel, A, Johnson, P.D, Kettle, J.G, Lane, C, Lamont, G, Leach, A, Luke, R.W.A, Ogilvie, D, Page, K, Pass, M, Steinbacher, S, Steuber, H, Pearson, S, Ruston, L. Deposit date: 2012-08-30 Release date: 2013-02-27 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Discovery of 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases. J.Med.Chem., 56, 2013
4FUL	PI3 Kinase Gamma bound to a pyrmidine inhibitor Descriptor: 4-({4-[3-(piperidin-1-ylcarbonyl)phenyl]pyrimidin-2-yl}amino)benzenesulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Authors: Gopalsamy, A, Bennett, E.M, Shi, M, Zhang, W.G, Bard, J, Yu, K. Deposit date: 2012-06-28 Release date: 2012-10-17 Last modified: 2012-10-31 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
8JOW	Crystal structure of rabbit antibody with phosphorylated peptide bound Descriptor: ARG-PRO-HIS-PHE-PRO-GLN-PHE-SEP-TYR-SER-ALA-SER, Antibody (scFv), CHLORIDE ION Authors: Caaveiro, J.M.M, Kawade, R, Tsumoto, K. Deposit date: 2023-06-08 Release date: 2024-06-12 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Origin of high binding affinity and selectivity of phosphorylated epitope-specific rabbit antibodies To Be Published
4KK1	Crystal Structure of TSC1 core domain from S. pombe Descriptor: Tuberous sclerosis 1 protein homolog Authors: Sun, W, Zhu, Y, Wang, Z.Z, Zhong, Q, Gao, F, Lou, J.Z, Gong, W.M, Xu, W.Q. Deposit date: 2013-05-05 Release date: 2013-07-17 Last modified: 2013-07-31 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun, 4, 2013
4KK0	Crystal Structure of TSC1 core domain from S. pombe Descriptor: Tuberous sclerosis 1 protein homolog Authors: Sun, W, Zhu, Y, Wang, Z.Z, Zhong, Q, Gao, F, Lou, J.Z, Gong, W.M, Xu, W.Q. Deposit date: 2013-05-05 Release date: 2013-07-17 Last modified: 2013-07-31 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations. Nat Commun, 4, 2013
3MVH	Crystal structure of Akt-1-inhibitor complexes Descriptor: GSK3-beta peptide, MANGANESE (II) ION, N-{[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl}-2,4-difluorobenzamide, ... Authors: Pandit, J. Deposit date: 2010-05-04 Release date: 2010-06-02 Last modified: 2021-10-06 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
3MV5	Crystal structure of Akt-1-inhibitor complexes Descriptor: (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine, GSK3-beta peptide, MANGANESE (II) ION, ... Authors: Pandit, J. Deposit date: 2010-05-03 Release date: 2010-06-02 Last modified: 2021-10-06 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
3M93	Complex crystal structure of Ascaris suum eIF4E-3 with m7G cap Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, Translation initiation factor 4E Authors: Liu, W, Berkeley Structural Genomics Center (BSGC) Deposit date: 2010-03-19 Release date: 2011-07-20 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation. Nucleic Acids Res., 39, 2011
3M94	Complex crystal structure of Ascaris suum eIF4E-3 with m2,2,7G cap Descriptor: ACETYL GROUP, Eukaryotic translation initiation factor 4E-binding protein 1, N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate), ... Authors: Liu, W, Berkeley Structural Genomics Center (BSGC) Deposit date: 2010-03-19 Release date: 2011-07-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation. Nucleic Acids Res., 39, 2011
5WKP	Crystal Structure of the Human mitochondrial Cysteine Desulfurase in complex with ISD11 and Iron-Sulfur Cluster Scaffold Protein ISCU1, and E. coli ACP1 protein at 3.15A Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... Authors: Boniecki, M.T, Cygler, M. Deposit date: 2017-07-25 Release date: 2017-11-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat Commun, 8, 2017
5WLW	Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A. Descriptor: Acyl carrier protein, Cysteine desulfurase, mitochondrial, ... Authors: Boniecki, M.T, Cygler, M. Deposit date: 2017-07-27 Release date: 2017-11-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.317 Å) Cite: Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat Commun, 8, 2017
7SOO	LaM domain of human LARP1 Descriptor: Isoform 2 of La-related protein 1, SODIUM ION, SULFATE ION Authors: Kozlov, G, Gehring, K. Deposit date: 2021-11-01 Release date: 2022-08-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural basis of 3'-end poly(A) RNA recognition by LARP1. Nucleic Acids Res., 50, 2022

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