4EKL

Akt1 with GDC0068

Summary for 4EKL

Entry DOI	10.2210/pdb4ekl/pdb
Related	4EKK
Descriptor	RAC-alpha serine/threonine-protein kinase, (2S)-2-(4-chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one (3 entities in total)
Functional Keywords	phosphotransferase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P31749
Total number of polymer chains	1
Total formula weight	39924.96
Authors	Wu, W.-I.,Vigers, G.P.A.,Morales, T.H.,Brandhuber, B.J. (deposition date: 2012-04-09, release date: 2012-05-23, Last modification date: 2018-01-24)
Primary citation	Lin, K.,Lin, J.,Wu, W.I.,Ballard, J.,Lee, B.B.,Gloor, S.L.,Vigers, G.P.,Morales, T.H.,Friedman, L.S.,Skelton, N.,Brandhuber, B.J. An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt. Sci.Signal., 5:ra37-ra37, 2012 Cited by PubMed: 22569334 DOI: 10.1126/scisignal.2002618 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation