4EKL
Akt1 with GDC0068
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RAC-alpha serine/threonine-protein kinase | polymer | 341 | 39467.0 | 1 | UniProt (P31749) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha |
| 2 | B (A) | (2S)-2-(4-chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one | non-polymer | 458.0 | 1 | Chemie (0RF) | |||
| 3 | C (A) | water | water | 18.0 | 318 | Chemie (HOH) |
Sequence modifications
A: 144 - 480 (UniProt: P31749)
| PDB | External Database | Details |
|---|---|---|
| Gly 140 | - | expression tag |
| Ala 141 | - | expression tag |
| Met 142 | - | expression tag |
| Ala 143 | - | expression tag |
| Asp 473 | Ser 473 | engineered mutation |
| Ser 478 | Gly 478 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39467.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 458.0 | |
| All* | Total formula weight | 39925.0 |
