4EKL
Akt1 with GDC0068
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RAC-alpha serine/threonine-protein kinase | polymer | 341 | 39467.0 | 1 | UniProt (P31749) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha |
| 2 | B (A) | (2S)-2-(4-chlorophenyl)-1-{4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl}-3-(propan-2-ylamino)propan-1-one | non-polymer | 458.0 | 1 | Chemie (0RF) PubChem (23649210) PubChem (24788740) PubChem (177749552) PubChem (146521423) PubChem (59670616) PubChem (59671085) PubChem (66618003) PubChem (67143839) PubChem (74078320) PubChem (118650358) PubChem (124560021) PubChem (124565372) PubChem (124652937) PubChem (134692697) PubChem (144453056) | |||
| 3 | C (A) | water | water | 18.0 | 318 | Chemie (HOH) |
Sequence modifications
A: 144 - 480 (UniProt: P31749)
| PDB | External Database | Details |
|---|---|---|
| Gly 140 | - | expression tag |
| Ala 141 | - | expression tag |
| Met 142 | - | expression tag |
| Ala 143 | - | expression tag |
| Asp 473 | Ser 473 | engineered mutation |
| Ser 478 | Gly 478 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39467.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 458.0 | |
| All* | Total formula weight | 39925.0 |
