3MVH
Crystal structure of Akt-1-inhibitor complexes
Summary for 3MVH
Entry DOI | 10.2210/pdb3mvh/pdb |
Related | 3CQU 3CQW 3MV5 3MVJ |
Descriptor | v-akt murine thymoma viral oncogene homolog 1 (AKT1), GSK3-beta peptide, MANGANESE (II) ION, ... (5 entities in total) |
Functional Keywords | kinase inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 41186.68 |
Authors | Pandit, J. (deposition date: 2010-05-04, release date: 2010-06-02, Last modification date: 2021-10-06) |
Primary citation | Freeman-Cook, K.D.,Autry, C.,Borzillo, G.,Gordon, D.,Barbacci-Tobin, E.,Bernardo, V.,Briere, D.,Clark, T.,Corbett, M.,Jakubczak, J.,Kakar, S.,Knauth, E.,Lippa, B.,Luzzio, M.J.,Mansour, M.,Martinelli, G.,Marx, M.,Nelson, K.,Pandit, J.,Rajamohan, F.,Robinson, S.,Subramanyam, C.,Wei, L.,Wythes, M.,Morris, J. Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53:4615-4622, 2010 Cited by PubMed: 20481595DOI: 10.1021/jm1003842 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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