6CO1
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6MY0
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6MXX
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![BU of 6mxx by Molmil](/molmil-images/mine/6mxx) | Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC2991 | Descriptor: | FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-iodobenzamide, PHOSPHATE ION, ... | Authors: | Cui, G, Botuyan, M.V, Mer, G. | Deposit date: | 2018-10-31 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.298 Å) | Cite: | An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nat Commun, 14, 2023
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4CRI
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![BU of 4cri by Molmil](/molmil-images/mine/4cri) | Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide | Descriptor: | RB1 PROTEIN, TUMOR SUPPRESSOR P53-BINDING PROTEIN 1 | Authors: | Krojer, T, Johansson, C, Gileadi, C, Fedorov, O, Carr, S, La Thangue, N.B, Vollmar, M, Crawley, L, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U. | Deposit date: | 2014-02-26 | Release date: | 2014-08-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Lysine Methylation-Dependent Binding of 53BP1 to the Prb Tumor Suppressor. Proc.Natl.Acad.Sci.USA, 111, 2014
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6CO2
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![BU of 6co2 by Molmil](/molmil-images/mine/6co2) | Structure of an engineered protein (NUDT16TI) in complex with 53BP1 Tudor domains | Descriptor: | NUDT16-Tudor-interacting (NUDT16TI), TP53-binding protein 1 | Authors: | Botuyan, M.V, Thompson, J.R, Cui, G, Mer, G. | Deposit date: | 2018-03-10 | Release date: | 2018-06-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat. Struct. Mol. Biol., 25, 2018
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1KZY
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![BU of 1kzy by Molmil](/molmil-images/mine/1kzy) | Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53 | Descriptor: | CELLULAR TUMOR ANTIGEN P53, TUMOR SUPPRESSOR P53-BINDING PROTEIN 1, ZINC ION | Authors: | Joo, W.S, Jeffrey, P.D, Cantor, S.B, Finnin, M.S, Livingston, D.M, Pavletich, N.P. | Deposit date: | 2002-02-08 | Release date: | 2002-03-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. Genes Dev., 16, 2002
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6MXZ
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![BU of 6mxz by Molmil](/molmil-images/mine/6mxz) | Structure of 53BP1 Tudor domains in complex with small molecule UNC3474 | Descriptor: | FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide, TP53-binding protein 1 | Authors: | Cui, G, Botuyan, M.V, Schuller, D.J, Mer, G. | Deposit date: | 2018-10-31 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nat Commun, 14, 2023
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5J26
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![BU of 5j26 by Molmil](/molmil-images/mine/5j26) | Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant | Descriptor: | Tumor suppressor p53-binding protein 1, Ubiquitin Variant i53 | Authors: | Wan, L, Canny, M, Juang, Y.C, Durocher, D, Sicheri, F. | Deposit date: | 2016-03-29 | Release date: | 2016-12-14 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.5047 Å) | Cite: | A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing To Be Published
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1GZH
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1XNI
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![BU of 1xni by Molmil](/molmil-images/mine/1xni) | Tandem Tudor Domain of 53BP1 | Descriptor: | Tumor suppressor p53-binding protein 1 | Authors: | Huyen, Y, Zgheib, O, DiTullio Jr, R.A, Gorgoulis, V.G, Zacharatos, P, Petty, T.J, Sheston, E.A, Mellert, H.S, Stavridi, E.S, Halazonetis, T.D. | Deposit date: | 2004-10-05 | Release date: | 2004-11-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks Nature, 432, 2004
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6RML
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![BU of 6rml by Molmil](/molmil-images/mine/6rml) | Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide | Descriptor: | 53BP1, DNA topoisomerase 2-binding protein 1 | Authors: | Day, M, Oliver, A.W, Pearl, L.H. | Deposit date: | 2019-05-07 | Release date: | 2019-06-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint. Elife, 8, 2019
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5ECG
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![BU of 5ecg by Molmil](/molmil-images/mine/5ecg) | Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX) | Descriptor: | Cellular tumor antigen p53, SEP-GLN-GLU-TYR, Tumor suppressor p53-binding protein 1, ... | Authors: | Day, M, Oliver, A.W, Pearl, L.H. | Deposit date: | 2015-10-20 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gamma H2AX. Cell Rep, 13, 2015
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7LIO
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7YQK
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![BU of 7yqk by Molmil](/molmil-images/mine/7yqk) | cryo-EM structure of gammaH2AXK15ub-H4K20me2 nucleosome bound to 53BP1 | Descriptor: | DNA (145-MER), Histone H2AX, Histone H2B, ... | Authors: | Ai, H.S, GuoChao, C, Qingyue, G, Ze-Bin, T, Zhiheng, D, Xin, L, Fan, Y, Ziyu, X, Jia-Bin, L, Changlin, T, Liu, L. | Deposit date: | 2022-08-07 | Release date: | 2022-08-17 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Chemical Synthesis of Post-Translationally Modified H2AX Reveals Redundancy in Interplay between Histone Phosphorylation, Ubiquitination, and Methylation on the Binding of 53BP1 with Nucleosomes. J.Am.Chem.Soc., 144, 2022
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6RMM
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8U4U
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5KGF
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![BU of 5kgf by Molmil](/molmil-images/mine/5kgf) | Structural model of 53BP1 bound to a ubiquitylated and methylated nucleosome, at 4.5 A resolution | Descriptor: | DNA (145-MER), Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, ... | Authors: | Wilson, M.D, Benlekbir, S, Sicheri, F, Rubinstein, J.L, Durocher, D. | Deposit date: | 2016-06-13 | Release date: | 2016-07-27 | Last modified: | 2020-01-15 | Method: | ELECTRON MICROSCOPY (4.54 Å) | Cite: | The structural basis of modified nucleosome recognition by 53BP1. Nature, 536, 2016
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2LVM
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2MWO
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2MWP
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