1GZH

Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor

Summary for 1GZH

Related1A1U 1AIE 1DT7 1HS5 1KZY 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1YCQ 1YCS 3SAK
DescriptorCELLULAR TUMOR ANTIGEN P53, TUMOR SUPPRESSOR P53-BINDING PROTEIN 1, ZINC ION, ... (6 entities in total)
Functional Keywordsgene regulation, anti-oncogene, dna-binding, transcription regulation, bcrt domain, apoptosis, disease mutation, activator, dna- repair
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm P04637 P04637
Nucleus Q12888
Total number of polymer chains4
Total molecular weight101411.68
Authors
Derbyshire, D.J.,Doherty, A.J. (deposition date: 2002-05-22, release date: 2002-06-27, Last modification date: 2014-02-05)
Primary citation
Derbyshire, D.J.,Basu, B.P.,Serpell, L.,Joo, W.,Date, T.,Iwabuchi, K.,Doherty, A.J.
Crystal Structure of Human 53BP1 Brct Domains Bound to P53 Tumour Suppressor
Embo J., 21:3863-, 2002
PubMed: 12110597 (PDB entries with the same primary citation)
DOI: 10.1093/EMBOJ/CDF383
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.236150.8%4.8%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report