Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX)

Summary for 5ECG

DescriptorCellular tumor antigen p53, Tumor suppressor p53-binding protein 1, SEP-GLN-GLU-TYR, ... (5 entities in total)
Functional Keywordsdna repair, nhej, h2ax, brct, antitumor protein
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm P04637
Nucleus Q12888
Total number of polymer chains6
Total molecular weight110952.06
Day, M.,Oliver, A.W.,Pearl, L.H. (deposition date: 2015-10-20, release date: 2015-12-16, Last modification date: 2015-12-30)
Primary citation
Baldock, R.A.,Day, M.,Wilkinson, O.J.,Cloney, R.,Jeggo, P.A.,Oliver, A.W.,Watts, F.Z.,Pearl, L.H.
ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gamma H2AX.
Cell Rep, 13:2081-2089, 2015
PubMed: 26628370 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2015.10.074
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26452.0%0.6%0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report