5ECG

Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cellular tumor antigen p53	polymer	225	25180.6	2	UniProt (P04637) Pfam (PF00870)	Homo sapiens (Human)	Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
2	C, D (C, D)	Tumor suppressor p53-binding protein 1	polymer	262	29624.5	2	UniProt (Q12888) Pfam (PF18428)	Homo sapiens (Human)	p53BP1
3	E, F (E, F)	SEP-GLN-GLU-TYR	polymer	4	605.5	2		Homo sapiens
4	G, H (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	I, J, K, L, M (A, B, C, D, E)	water	water		18.0	17	Chemie (HOH)

Sequence modifications

A, B: 95 - 312 (UniProt: P04637)

PDB	External Database	Details
Gly 88	-	expression tag
Pro 89	-	expression tag
Leu 90	-	expression tag
Gly 91	-	expression tag
Ser 92	-	expression tag
His 93	-	expression tag
Met 94	-	expression tag

C, D: 1713 - 1972 (UniProt: Q12888)

PDB	External Database	Details
His 1711	-	expression tag
Met 1712	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	110821.2
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	110952.1

*Water molecules are not included.