6MXZ

Structure of 53BP1 Tudor domains in complex with small molecule UNC3474

Summary for 6MXZ

Entry DOI	10.2210/pdb6mxz/pdb
Descriptor	TP53-binding protein 1, N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide, FORMIC ACID, ... (4 entities in total)
Functional Keywords	dna damage response, tudor domain, 53bp1, small molecule inhibitor, protein binding
Biological source	Homo sapiens (Human)
Total number of polymer chains	10
Total formula weight	141152.06
Authors	Cui, G.,Botuyan, M.V.,Schuller, D.J.,Mer, G. (deposition date: 2018-10-31, release date: 2019-11-27, Last modification date: 2023-10-11)
Primary citation	Cui, G.,Botuyan, M.V.,Drane, P.,Hu, Q.,Bragantini, B.,Thompson, J.R.,Schuller, D.J.,Detappe, A.,Perfetti, M.T.,James, L.I.,Frye, S.V.,Chowdhury, D.,Mer, G. An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nat Commun, 14:6091-6091, 2023 Cited by PubMed: 37773238 DOI: 10.1038/s41467-023-41821-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation