6MXZ
Structure of 53BP1 Tudor domains in complex with small molecule UNC3474
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue K6S A 1701 |
| Chain | Residue |
| A | TRP1495 |
| B | ASP1521 |
| B | TYR1523 |
| B | MET1584 |
| A | TYR1502 |
| A | PHE1519 |
| A | ASP1521 |
| A | TYR1523 |
| A | MET1584 |
| B | TRP1495 |
| B | TYR1502 |
| B | PHE1519 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue FMT B 1701 |
| Chain | Residue |
| B | GLU1564 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue K6S D 1701 |
| Chain | Residue |
| C | TRP1495 |
| C | TYR1502 |
| C | ASP1521 |
| C | TYR1523 |
| C | MET1584 |
| D | TRP1495 |
| D | TYR1502 |
| D | ASP1521 |
| D | TYR1523 |
| D | MET1584 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue FMT D 1702 |
| Chain | Residue |
| C | GLU1567 |
| C | LYS1582 |
| D | SER1548 |
| D | TRP1580 |
| D | HOH1801 |
| D | HOH1814 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue FMT D 1703 |
| Chain | Residue |
| D | GLU1564 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue K6S E 1701 |
| Chain | Residue |
| E | TRP1495 |
| E | TYR1502 |
| E | PHE1519 |
| E | ASP1521 |
| E | TYR1523 |
| E | MET1584 |
| F | TRP1495 |
| F | TYR1502 |
| F | ASP1521 |
| F | TYR1523 |
| F | MET1584 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue FMT F 1701 |
| Chain | Residue |
| E | TRP1580 |
| F | GLU1567 |
| F | LYS1582 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue FMT F 1702 |
| Chain | Residue |
| F | HIS1561 |
| F | TRP1580 |
| F | HOH1808 |
| F | HOH1815 |
| J | HIS1561 |
| J | TRP1580 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue FMT G 1701 |
| Chain | Residue |
| G | GLU1564 |
| site_id | AD1 |
| Number of Residues | 11 |
| Details | binding site for residue K6S H 1701 |
| Chain | Residue |
| G | TRP1495 |
| G | TYR1502 |
| G | ASP1521 |
| G | TYR1523 |
| G | MET1584 |
| H | TRP1495 |
| H | TYR1502 |
| H | PHE1519 |
| H | ASP1521 |
| H | TYR1523 |
| H | MET1584 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT H 1702 |
| Chain | Residue |
| G | GLU1567 |
| G | LYS1582 |
| H | SER1548 |
| H | TRP1580 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue K6S I 1701 |
| Chain | Residue |
| I | TRP1495 |
| I | TYR1502 |
| I | PHE1519 |
| I | ASP1521 |
| I | TYR1523 |
| I | MET1584 |
| J | TYR1502 |
| J | SER1503 |
| J | PHE1519 |
| J | ASP1521 |
| J | MET1584 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 280 |
| Details | Region: {"description":"Interaction with dimethylated histone H4","evidences":[{"source":"PubMed","id":"17190600","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 476 |
| Details | Region: {"description":"Tudor-like","evidences":[{"source":"PubMed","id":"17190600","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
