7YQK

cryo-EM structure of gammaH2AXK15ub-H4K20me2 nucleosome bound to 53BP1

Summary for 7YQK

Entry DOI	10.2210/pdb7yqk/pdb
EMDB information	34028
Descriptor	Histone H3.1, Histone H4, Histone H2AX, ... (9 entities in total)
Functional Keywords	nucleosoeme, 53bp1, complex, h4k20me2, h2axk15ub, gammah2ax, nuclear protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	13
Total formula weight	201815.41
Authors	Ai, H.S.,GuoChao, C.,Qingyue, G.,Ze-Bin, T.,Zhiheng, D.,Xin, L.,Fan, Y.,Ziyu, X.,Jia-Bin, L.,Changlin, T.,Liu, L. (deposition date: 2022-08-07, release date: 2022-08-17, Last modification date: 2024-07-03)
Primary citation	Ai, H.,Chu, G.C.,Gong, Q.,Tong, Z.B.,Deng, Z.,Liu, X.,Yang, F.,Xu, Z.,Li, J.B.,Tian, C.,Liu, L. Chemical Synthesis of Post-Translationally Modified H2AX Reveals Redundancy in Interplay between Histone Phosphorylation, Ubiquitination, and Methylation on the Binding of 53BP1 with Nucleosomes. J.Am.Chem.Soc., 144:18329-18337, 2022 Cited by PubMed: 36166692 DOI: 10.1021/jacs.2c06156 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.38 Å)

Structure validation