7YQK
cryo-EM structure of gammaH2AXK15ub-H4K20me2 nucleosome bound to 53BP1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3.1 | polymer | 100 | 11762.8 | 2 | UniProt (P68431) Pfam (PF00125) | Homo sapiens (human) | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
| 2 | B, F (B, F) | Histone H4 | polymer | 83 | 9409.1 | 2 | UniProt (A0A672PXK1) Pfam (PF15511) UniProt (by SIFTS) (P62805) | Homo sapiens (human) | |
| 3 | C, G (C, G) | Histone H2AX | polymer | 112 | 12194.2 | 2 | UniProt (A0A6P5QZC6) Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P16104) | synthetic construct | |
| 4 | D, H (D, H) | Histone H2B | polymer | 96 | 10764.4 | 2 | UniProt (Q2M2T1) Pfam (PF00125) UniProt (by SIFTS) (O60814) | Homo sapiens (human) | |
| 5 | I (I) | DNA (145-MER) | polymer | 145 | 44520.4 | 1 | synthetic construct | ||
| 6 | J (J) | DNA (145-MER) | polymer | 145 | 44991.7 | 1 | synthetic construct | ||
| 7 | K (O) | Polyubiquitin-B | polymer | 75 | 8519.8 | 1 | UniProt (J3QS39) Pfam (PF00240) UniProt (by SIFTS) (P0CG47) | Homo sapiens (human) | |
| 8 | L (K) | UDR motif of 53BP1 | polymer | 18 | 2075.4 | 1 | UniProt (by SIFTS) (Q12888) | Homo sapiens | |
| 9 | M (N) | TP53-binding protein 1 | polymer | 118 | 13447.2 | 1 | UniProt (A6NNK5) Pfam (PF09038) UniProt (by SIFTS) (Q12888) | Homo sapiens (human) |
Sequence modifications
C, G: 10 - 121 (UniProt: A0A6P5QZC6)
| PDB | External Database | Details |
|---|---|---|
| Cys 15 | Lys 16 | conflict |
| His 38 | Asn 39 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 13 |
| Total formula weight | 201815.4 | |
| All* | Total formula weight | 201815.4 |
