8U4U

Crystal structure of 53BP1 tandem Tudor domain homodimer engineered with two disulfide bridges

Summary for 8U4U

Entry DOI	10.2210/pdb8u4u/pdb
Related	6MXX 6MXY 6MXZ 6MY0
Descriptor	TP53-binding protein 1 (1 entity in total)
Functional Keywords	53bp1, dna damage response, dna double-strand break repair, non-homologous end joining, homologous recombination, chromatin-binding protein, engineered protein, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	10
Total formula weight	140470.06
Authors	Cui, G.,Botuyan, M.V.,Thompson, J.R.,Mer, G. (deposition date: 2023-09-11, release date: 2023-09-20, Last modification date: 2023-10-11)
Primary citation	Cui, G.,Botuyan, M.V.,Drane, P.,Hu, Q.,Bragantini, B.,Thompson, J.R.,Schuller, D.J.,Detappe, A.,Perfetti, M.T.,James, L.I.,Frye, S.V.,Chowdhury, D.,Mer, G. An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nat Commun, 14:6091-6091, 2023 Cited by PubMed: 37773238 DOI: 10.1038/s41467-023-41821-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.79 Å)

Structure validation