1KZY

Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53

Summary for 1KZY

DescriptorCELLULAR TUMOR ANTIGEN P53, TUMOR SUPPRESSOR P53-BINDING PROTEIN 1, ZINC ION, ... (4 entities in total)
Functional Keywordstandem-brct and linker complexed with non-brct protein, three-helix bundle, parallel beta sheet, dna binding protein, protein binding
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm P04637
Nucleus Q12888
Total number of polymer chains4
Total molecular weight102558.84
Authors
Joo, W.S.,Jeffrey, P.D.,Cantor, S.B.,Finnin, M.S.,Livingston, D.M.,Pavletich, N.P. (deposition date: 2002-02-08, release date: 2002-03-20, Last modification date: 2011-07-13)
Primary citation
Joo, W.S.,Jeffrey, P.D.,Cantor, S.B.,Finnin, M.S.,Livingston, D.M.,Pavletich, N.P.
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
Genes Dev., 16:583-593, 2002
PubMed: 11877378 (PDB entries with the same primary citation)
DOI: 10.1101/gad.959202
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers212.4%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report