7ZK3
| Structure of 1PBC- and calcium-bound mTMEM16A(ac) chloride channel at 2.85 A resolution | Descriptor: | 1-Hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile, Anoctamin-1, CALCIUM ION | Authors: | Lam, A.K.M, Rutz, S, Dutzler, R. | Deposit date: | 2022-04-12 | Release date: | 2022-05-25 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC. Nat Commun, 13, 2022
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8BC1
| Cryo-EM Structure of Ca2+-bound mTMEM16F F518A_Q623A mutant in GDN | Descriptor: | Anoctamin-6,mTMEM16F, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-14 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8B8G
| Cryo-EM structure of Ca2+-free mTMEM16F F518H mutant in Digitonin | Descriptor: | Anoctamin-6 | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-04 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8BC0
| Cryo-EM structure of Ca2+-bound mTMEM16F F518A Q623A mutant in GDN open/closed | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-14 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8B8J
| Cryo-EM structure of Ca2+-bound mTMEM16F F518H mutant in Digitonin | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-04 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8B8M
| Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin open/closed | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-04 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8B8K
| Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin closed/closed | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-04 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8B8Q
| Structure of mTMEM16F in lipid Nanodiscs in the presence of Ca2+ | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-04 | Release date: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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6OY3
| nhTMEM16 L302A +Ca2+ in nanodiscs | Descriptor: | CALCIUM ION, nhTMEM16 | Authors: | Falzone, M, Lee, B.C, Accardi, A. | Deposit date: | 2019-05-14 | Release date: | 2019-11-06 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca 2+ -bound nhTMEM16. Nat Commun, 10, 2019
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6P49
| Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl2 | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | Deposit date: | 2019-05-26 | Release date: | 2019-07-24 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep, 28, 2019
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6P46
| Cryo-EM structure of TMEM16F in digitonin with calcium bound | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | Deposit date: | 2019-05-26 | Release date: | 2019-07-24 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep, 28, 2019
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6P47
| Cryo-EM structure of TMEM16F in digitonin without calcium | Descriptor: | Anoctamin-6 | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | Deposit date: | 2019-05-26 | Release date: | 2019-07-24 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep, 28, 2019
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6P48
| Cryo-EM structure of calcium-bound TMEM16F in nanodisc with supplement of PIP2 in Cl1 | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Feng, S, Dang, S, Han, T.W, Ye, W, Jin, P, Cheng, T, Li, J, Jan, Y.N, Jan, L.Y, Cheng, Y. | Deposit date: | 2019-05-26 | Release date: | 2019-07-24 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling. Cell Rep, 28, 2019
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6QMB
| Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in nanodisc (closed state) | Descriptor: | CALCIUM ION, Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QPB
| Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in digitonin | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6 | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-13 | Release date: | 2019-03-06 | Last modified: | 2019-03-20 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QM9
| Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in nanodisc (open state) | Descriptor: | CALCIUM ION, Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QM4
| Cryo-EM structure of calcium-free nhTMEM16 lipid scramblase in nanodisc | Descriptor: | Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QM6
| Cryo-EM structure of calcium-free nhTMEM16 lipid scramblase in DDM | Descriptor: | Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QMA
| Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in nanodisc (intermediate state) | Descriptor: | CALCIUM ION, Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QP6
| Cryo-EM structure of calcium-bound mTMEM16F lipid scramblase in digitonin | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6, CALCIUM ION | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-13 | Release date: | 2019-03-06 | Last modified: | 2019-04-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QPI
| Cryo-EM structure of calcium-free mTMEM16F lipid scramblase in nanodisc | Descriptor: | Anoctamin-6 | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-14 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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6QM5
| Cryo-EM structure of calcium-bound nhTMEM16 lipid scramblase in DDM | Descriptor: | CALCIUM ION, Predicted protein | Authors: | Kalienkova, V, Clerico Mosina, V, Bryner, L, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-01 | Release date: | 2019-03-06 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM. Elife, 8, 2019
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6QPC
| Cryo-EM structure of calcium-bound mTMEM16F lipid scramblase in nanodisc | Descriptor: | 1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-6, CALCIUM ION | Authors: | Alvadia, C, Lim, N.K, Clerico Mosina, V, Oostergetel, G.T, Dutzler, R, Paulino, C. | Deposit date: | 2019-02-13 | Release date: | 2019-03-06 | Last modified: | 2019-04-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife, 8, 2019
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8QZC
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8TAG
| TMEM16F, with Calcium and PIP2, no inhibitor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Anoctamin-6, CALCIUM ION | Authors: | Feng, S, Cheng, Y. | Deposit date: | 2023-06-27 | Release date: | 2023-09-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun, 14, 2023
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