8KG5
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![BU of 8kg5 by Molmil](/molmil-images/mine/8kg5) | Prefusion RSV F Bound to Lonafarnib and D25 Fab | Descriptor: | 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, D25 heavy chain, D25 light chain, ... | Authors: | Yang, Q, Xue, B, Liu, F, Peng, W, Chen, X. | Deposit date: | 2023-08-17 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein. Signal Transduct Target Ther, 9, 2024
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5J5N
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5J4U
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![BU of 5j4u by Molmil](/molmil-images/mine/5j4u) | |
3Q2T
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![BU of 3q2t by Molmil](/molmil-images/mine/3q2t) | Crystal Structure of CFIm68 RRM/CFIm25/RNA complex | Descriptor: | Cleavage and polyadenylation specificity factor subunit 5, Cleavage and polyadenylation specificity factor subunit 6, RNA | Authors: | Yang, Q, Coseno, M, Gilmartin, G.M, Doublie, S. | Deposit date: | 2010-12-20 | Release date: | 2011-02-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.061 Å) | Cite: | Crystal Structure of a Human Cleavage Factor CFI(m)25/CFI(m)68/RNA Complex Provides an Insight into Poly(A) Site Recognition and RNA Looping. Structure, 19, 2011
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8Z9U
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![BU of 8z9u by Molmil](/molmil-images/mine/8z9u) | |
3MDG
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![BU of 3mdg by Molmil](/molmil-images/mine/3mdg) | |
3MDI
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![BU of 3mdi by Molmil](/molmil-images/mine/3mdi) | |
4GO5
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![BU of 4go5 by Molmil](/molmil-images/mine/4go5) | |
4GO7
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3Q2S
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![BU of 3q2s by Molmil](/molmil-images/mine/3q2s) | Crystal Structure of CFIm68 RRM/CFIm25 complex | Descriptor: | Cleavage and polyadenylation specificity factor subunit 5, Cleavage and polyadenylation specificity factor subunit 6 | Authors: | Yang, Q, Coseno, M, Gilmartin, G.M, Doublie, S. | Deposit date: | 2010-12-20 | Release date: | 2011-02-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of a Human Cleavage Factor CFI(m)25/CFI(m)68/RNA Complex Provides an Insight into Poly(A) Site Recognition and RNA Looping. Structure, 19, 2011
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4N5X
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4LT6
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![BU of 4lt6 by Molmil](/molmil-images/mine/4lt6) | Crystal Structure of human poly(A) polymerase gamma | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Poly(A) polymerase gamma | Authors: | Yang, Q, Nausch, L, Martin, G, Keller, W, Doublie, S. | Deposit date: | 2013-07-23 | Release date: | 2013-10-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases. J.Mol.Biol., 426, 2014
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6JKF
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![BU of 6jkf by Molmil](/molmil-images/mine/6jkf) | Crystal structure of Serratia marcescens Chitinase B complexed with compound 2-8-s2 | Descriptor: | 6-azanyl-11-methyl-2-oxidanylidene-7-[[(2R)-oxolan-2-yl]methyl]-N-(pyridin-3-ylmethyl)-1,9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-3(8),4,6,9,11,13-hexaene-5-carboxamide, Chitinase | Authors: | Yang, Q, Jiang, X. | Deposit date: | 2019-02-28 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. J.Med.Chem., 63, 2020
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8HP6
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![BU of 8hp6 by Molmil](/molmil-images/mine/8hp6) | Crystal structure of (S)-2-haloacid dehalogenase D12A mutant | Descriptor: | (S)-2-haloacid dehalogenase, SODIUM ION | Authors: | Yang, Q, Wang, L, Xu, X, Xing, X, Zhou, J. | Deposit date: | 2022-12-12 | Release date: | 2023-06-21 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Enzymatic hydrolysis on L-azetidine-2-carboxylate ring opening Catalysis Science And Technology, 2023
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8HP5
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![BU of 8hp5 by Molmil](/molmil-images/mine/8hp5) | Crystal structure of (S)-2-haloacid dehalogenase | Descriptor: | (S)-2-haloacid dehalogenase, 1,2-ETHANEDIOL | Authors: | Yang, Q, Wang, L, Xu, X, Xing, X, Zhou, J. | Deposit date: | 2022-12-12 | Release date: | 2023-06-21 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Enzymatic hydrolysis on L-azetidine-2-carboxylate ring opening Catalysis Science And Technology, 2023
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8HP7
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![BU of 8hp7 by Molmil](/molmil-images/mine/8hp7) | Crystal structure of (S)-2-haloacid dehalogenase K152A mutant trapped with (2R)-4-amino-2-hydroxybutanoic acid | Descriptor: | (S)-2-haloacid dehalogenase, 1,2-ETHANEDIOL, GAMMA-AMINO-BUTANOIC ACID | Authors: | Yang, Q, Wang, L, Xu, X, Xing, X, Zhou, J. | Deposit date: | 2022-12-12 | Release date: | 2023-06-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Enzymatic hydrolysis on L-azetidine-2-carboxylate ring opening Catalysis Science And Technology, 2023
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7Y7N
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![BU of 7y7n by Molmil](/molmil-images/mine/7y7n) | |
5GQB
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![BU of 5gqb by Molmil](/molmil-images/mine/5gqb) | Crystal structure of chitinase-h from O. furnacalis in complex with chitohepatose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, ... | Authors: | Liu, T, Zhou, Y, Chen, L, Yang, Q. | Deposit date: | 2016-08-06 | Release date: | 2017-01-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure, Catalysis, and Inhibition of OfChi-h, the Lepidoptera-exclusive Insect Chitinase. J. Biol. Chem., 292, 2017
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3X21
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![BU of 3x21 by Molmil](/molmil-images/mine/3x21) | Crystal structure of Escherichia coli nitroreductase NfsB mutant T41L/N71S/F124W | Descriptor: | FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase | Authors: | Bai, J, Yang, J, Zhou, Y, Yang, Q. | Deposit date: | 2014-12-06 | Release date: | 2015-05-20 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.002 Å) | Cite: | Altering the regioselectivity of a nitroreductase in the synthesis of arylhydroxylamines by structure-based engineering. Chembiochem, 16, 2015
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3X22
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![BU of 3x22 by Molmil](/molmil-images/mine/3x22) | Crystal structure of Escherichia coli nitroreductase NfsB mutant N71S/F123A/F124W | Descriptor: | FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase | Authors: | Bai, J, Yang, J, Zhou, Y, Yang, Q. | Deposit date: | 2014-12-06 | Release date: | 2015-11-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural basis of Escherichia coli nitroreductase NfsB triple mutants engineered for improved activity and regioselectivity toward the prodrug CB1954 PROCESS BIOCHEM, 50, 2015
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3WMC
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![BU of 3wmc by Molmil](/molmil-images/mine/3wmc) | Crystal structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with naphthalimide derivative Q2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(dimethylamino)-2-(2-{[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]amino}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione, Beta-hexosaminidase | Authors: | Chen, L, Zhou, Y, Chen, L, Yang, Q. | Deposit date: | 2013-11-16 | Release date: | 2014-11-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.095 Å) | Cite: | A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs Sci Rep, 4, 2014
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3WMB
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![BU of 3wmb by Molmil](/molmil-images/mine/3wmb) | Crystal structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with naphthalimide derivative Q1 | Descriptor: | 2-(2-{[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]amino}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-hexosaminidase | Authors: | Liu, T, Zhou, Y, Chen, L, Yang, Q. | Deposit date: | 2013-11-16 | Release date: | 2014-11-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs Sci Rep, 4, 2014
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3WL0
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![BU of 3wl0 by Molmil](/molmil-images/mine/3wl0) | Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain E148A mutant in complex with a(GlcNAc)2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase | Authors: | Chen, L, Liu, T, Zhou, Y, Chen, Q, Shen, X, Yang, Q. | Deposit date: | 2013-11-05 | Release date: | 2014-04-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.204 Å) | Cite: | Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting. Acta Crystallogr.,Sect.D, 70, 2014
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3WKZ
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![BU of 3wkz by Molmil](/molmil-images/mine/3wkz) | Crystal Structure of the Ostrinia furnacalis Group I Chitinase catalytic domain E148Q mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase | Authors: | Chen, L, Liu, T, Zhou, Y, Chen, Q, Shen, X, Yang, Q. | Deposit date: | 2013-11-05 | Release date: | 2014-04-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting. Acta Crystallogr.,Sect.D, 70, 2014
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3WL1
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![BU of 3wl1 by Molmil](/molmil-images/mine/3wl1) | Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with reaction products (GlcNAc)2,3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chen, L, Liu, T, Zhou, Y, Chen, Q, Shen, X, Yang, Q. | Deposit date: | 2013-11-05 | Release date: | 2014-04-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.772 Å) | Cite: | Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting. Acta Crystallogr.,Sect.D, 70, 2014
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