8KG5

Prefusion RSV F Bound to Lonafarnib and D25 Fab

Summary for 8KG5

Entry DOI	10.2210/pdb8kg5/pdb
EMDB information	37210
Descriptor	Fusion glycoprotein F0,Fibritin, D25 heavy chain, D25 light chain, ... (4 entities in total)
Functional Keywords	respiratory syncytial virus, f protein, lonafarnib, viral protein/immune system, viral protein-immune system complex
Biological source	Human respiratory syncytial virus A (strain A2) More
Total number of polymer chains	5
Total formula weight	243338.77
Authors	Yang, Q.,Xue, B.,Liu, F.,Peng, W.,Chen, X. (deposition date: 2023-08-17, release date: 2024-06-19)
Primary citation	Yang, Q.,Xue, B.,Liu, F.,Lu, Y.,Tang, J.,Yan, M.,Wu, Q.,Chen, R.,Zhou, A.,Liu, L.,Liu, J.,Qu, C.,Wu, Q.,Fu, M.,Zhong, J.,Dong, J.,Chen, S.,Wang, F.,Zhou, Y.,Zheng, J.,Peng, W.,Shang, J.,Chen, X. Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein. Signal Transduct Target Ther, 9:144-144, 2024 Cited by PubMed: 38853183 DOI: 10.1038/s41392-024-01858-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.17 Å)

Structure validation