3X22

Crystal structure of Escherichia coli nitroreductase NfsB mutant N71S/F123A/F124W

Summary for 3X22

• Entry DOI: 10.2210/pdb3x22/pdb
• Related: 1DS7 3X21
• Descriptor: Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE (3 entities in total)
• Functional Keywords: nitroreductase, regioselectivity, prodrug activation, cb1954, oxidoreductase
• Biological source: Escherichia coli K-12
• Total number of polymer chains: 2
• Total formula weight: 53001.62

Authors

Bai, J.,Yang, J.,Zhou, Y.,Yang, Q. (deposition date: 2014-12-06, release date: 2015-11-18, Last modification date: 2023-11-08)

• Primary citation: Bai, J.,Yang, J.,Zhou, Y.,Yang, Q.; Structural basis of Escherichia coli nitroreductase NfsB triple mutants engineered for improved activity and regioselectivity toward the prodrug CB1954; PROCESS BIOCHEM, 50:1760-1766, 2015; DOI: 10.1016/j.procbio.2015.08.012

Experimental method

X-RAY DIFFRACTION (2.001 Å)