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3WMC

Crystal structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with naphthalimide derivative Q2

Summary for 3WMC
Entry DOI10.2210/pdb3wmc/pdb
Related3NSM 3NSN 3OZO 3OZP 3S6T 3VTR 3WMB
DescriptorBeta-hexosaminidase, 6-(dimethylamino)-2-(2-{[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]amino}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywordschitinase, glycosyl hydrolase, insect, ostrinia furnacalis, hydrolase
Biological sourceOstrinia furnacalis (Asian corn borer)
Total number of polymer chains1
Total formula weight66389.80
Authors
Chen, L.,Zhou, Y.,Chen, L.,Yang, Q. (deposition date: 2013-11-16, release date: 2014-11-05, Last modification date: 2023-11-08)
Primary citationLiu, T.,Guo, P.,Zhou, Y.,Wang, J.,Chen, L.,Yang, H.,Qian, X.,Yang, Q.
A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs
Sci Rep, 4:6188-6188, 2014
Cited by
PubMed: 25155420
DOI: 10.1038/srep06188
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.095 Å)
Structure validation

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