4PV7
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![BU of 4pv7 by Molmil](/molmil-images/mine/4pv7) | Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor | 分子名称: | 1-[2-(2,4-dichlorophenyl)-1-(methylsulfonyl)-1H-indol-3-yl]methanamine, Dipeptidyl peptidase 4 soluble form | 著者 | Xiao, P, Guo, R, Huang, S, Cui, H, Ye, S, Zhang, Z. | 登録日 | 2014-03-15 | 公開日 | 2015-03-18 | 実験手法 | X-RAY DIFFRACTION (3.24 Å) | 主引用文献 | Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold Chin.Chem.Lett., 25, 2014
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4QBE
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![BU of 4qbe by Molmil](/molmil-images/mine/4qbe) | The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop | 分子名称: | Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X. | 登録日 | 2014-05-08 | 公開日 | 2014-12-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.292 Å) | 主引用文献 | The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
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4QBW
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![BU of 4qbw by Molmil](/molmil-images/mine/4qbw) | The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. | 登録日 | 2014-05-08 | 公開日 | 2015-02-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.912 Å) | 主引用文献 | The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
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4QAP
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![BU of 4qap by Molmil](/molmil-images/mine/4qap) | The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. | 登録日 | 2014-05-05 | 公開日 | 2015-02-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | 主引用文献 | The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
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4QAH
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![BU of 4qah by Molmil](/molmil-images/mine/4qah) | The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Bi, W.X. | 登録日 | 2014-05-05 | 公開日 | 2014-12-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.403 Å) | 主引用文献 | The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
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8ID6
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![BU of 8id6 by Molmil](/molmil-images/mine/8id6) | Cryo-EM structure of the oleic acid bound GPR120-Gi complex | 分子名称: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID9
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![BU of 8id9 by Molmil](/molmil-images/mine/8id9) | Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex | 分子名称: | 5,8,11,14,17-EICOSAPENTAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID4
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![BU of 8id4 by Molmil](/molmil-images/mine/8id4) | Cryo-EM structure of the linoleic acid bound GPR120-Gi complex | 分子名称: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID3
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![BU of 8id3 by Molmil](/molmil-images/mine/8id3) | Cryo-EM structure of the 9-hydroxystearic acid bound GPR120-Gi complex | 分子名称: | 9-Hydroxyoctadecanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID8
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![BU of 8id8 by Molmil](/molmil-images/mine/8id8) | Cryo-EM structure of the TUG891 bound GPR120-Gi complex | 分子名称: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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7DFB
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![BU of 7dfb by Molmil](/molmil-images/mine/7dfb) | Crystal of Arrestin2-V2Rpp-6-7-Fab30 complex | 分子名称: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | 著者 | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | 登録日 | 2020-11-06 | 公開日 | 2021-07-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.28 Å) | 主引用文献 | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7DFA
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![BU of 7dfa by Molmil](/molmil-images/mine/7dfa) | Crystal of Arrestin2-V2Rpp-4-Fab30 complex | 分子名称: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | 著者 | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | 登録日 | 2020-11-06 | 公開日 | 2021-07-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7DF9
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![BU of 7df9 by Molmil](/molmil-images/mine/7df9) | Crystal of Arrestin2-V2Rpp-1-Fab30 complex | 分子名称: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | 著者 | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | 登録日 | 2020-11-06 | 公開日 | 2021-07-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | 主引用文献 | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7DFC
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![BU of 7dfc by Molmil](/molmil-images/mine/7dfc) | Crystal of Arrestin2-V2Rpp-3-Fab30 complex | 分子名称: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | 著者 | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | 登録日 | 2020-11-06 | 公開日 | 2021-07-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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4RAF
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![BU of 4raf by Molmil](/molmil-images/mine/4raf) | Crystal structure of PP2Ca-D38A | 分子名称: | MANGANESE (II) ION, Protein phosphatase 1A | 著者 | Pan, C, Tang, J.Y, Xu, Y.F, Xiao, P, Liu, H.D, Wang, H.A, Wang, W.B, Meng, F.G, Yu, X, Sun, J.P. | 登録日 | 2014-09-10 | 公開日 | 2015-08-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | The catalytic role of the M2 metal ion in PP2C alpha Sci Rep, 5, 2015
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4RA2
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![BU of 4ra2 by Molmil](/molmil-images/mine/4ra2) | PP2Ca | 分子名称: | MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A | 著者 | Pan, C, Tang, J.Y, Xu, Y.F, Xiao, P, Liu, H.D, Wang, H.A, Wang, W.B, Meng, F.G, Yu, X, Sun, J.P. | 登録日 | 2014-09-09 | 公開日 | 2015-05-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | The catalytic role of the M2 metal ion in PP2Ca SCI REP, 2015
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5J8R
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![BU of 5j8r by Molmil](/molmil-images/mine/5j8r) | Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant | 分子名称: | Tyrosine-protein phosphatase non-receptor type 12 | 著者 | Li, H, Yang, F, Xu, Y.F, Wang, W.J, Xiao, P, Yu, X, Sun, J.P. | 登録日 | 2016-04-08 | 公開日 | 2016-04-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.043 Å) | 主引用文献 | Crystal structure and substrate specificity of PTPN12. Cell Rep, 15, 2016
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7D77
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![BU of 7d77 by Molmil](/molmil-images/mine/7d77) | Cryo-EM structure of the cortisol-bound adhesion receptor GPR97-Go complex | 分子名称: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ... | 著者 | Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J. | 登録日 | 2020-10-03 | 公開日 | 2021-02-03 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex. Nature, 589, 2021
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7D76
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![BU of 7d76 by Molmil](/molmil-images/mine/7d76) | Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97-Go complex | 分子名称: | (8~{S},9~{R},10~{S},11~{S},13~{S},14~{S},16~{S},17~{R})-9-chloranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, Adhesion G protein-coupled receptor G3; GPR97, CHOLESTEROL, ... | 著者 | Ping, Y, Mao, C, Xiao, P, Zhao, R, Jiang, Y, Yang, Z, An, W, Shen, D, Yang, F, Zhang, H, Qu, C, Shen, Q, Tian, C, Li, Z, Li, S, Wang, G, Tao, X, Wen, X, Zhong, Y, Yang, J, Yi, F, Yu, X, Xu, E, Zhang, Y, Sun, J. | 登録日 | 2020-10-03 | 公開日 | 2021-02-03 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structures of the glucocorticoid-bound adhesion receptor GPR97-G o complex. Nature, 589, 2021
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8G59
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![BU of 8g59 by Molmil](/molmil-images/mine/8g59) | Cryo-EM structure of the TUG891 bound GPR120-Giq complex | 分子名称: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-08 | 最終更新日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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7CKG
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![BU of 7ckg by Molmil](/molmil-images/mine/7ckg) | Crystal structure of TMSiPheRS complexed with TMSiPhe | 分子名称: | 4-(trimethylsilyl)-L-phenylalanine, Tyrosine--tRNA ligase | 著者 | Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P. | 登録日 | 2020-07-17 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | 主引用文献 | DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe. Nat Commun, 11, 2020
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7CKH
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![BU of 7ckh by Molmil](/molmil-images/mine/7ckh) | Crystal structure of TMSiPheRS | 分子名称: | Tyrosine--tRNA ligase | 著者 | Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P. | 登録日 | 2020-07-17 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.79492676 Å) | 主引用文献 | DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe. Nat Commun, 11, 2020
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7TS0
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![BU of 7ts0 by Molmil](/molmil-images/mine/7ts0) | Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein | 分子名称: | Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Human corticotropin releasing factor receptor 2, Dominant negative Go alpha subunit, G protein gamma subunit, ... | 著者 | Zhao, L.-H, Lin, J, Mao, C, Zhou, X.E, Ji, S, Shen, D, Xiao, P, Melcher, K, Zhang, Y, Yu, X, Xu, H.E. | 登録日 | 2022-01-31 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor. Nat Commun, 13, 2022
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7TRY
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![BU of 7try by Molmil](/molmil-images/mine/7try) | Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein | 分子名称: | Corticotropin-releasing factor receptor 2, G protein gamma subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhao, L.-H, Lin, J, Mao, C, Zhou, X.E, Ji, S, Shen, D, Xiao, P, Melcher, K, Zhang, Y, Yu, X, Xu, H.E. | 登録日 | 2022-01-31 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor. Nat Commun, 13, 2022
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7CX4
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![BU of 7cx4 by Molmil](/molmil-images/mine/7cx4) | Cryo-EM structure of the Evatanepag-bound EP2-Gs complex | 分子名称: | 2-[3-[[(4-~{tert}-butylphenyl)methyl-pyridin-3-ylsulfonyl-amino]methyl]phenoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Qu, C, Mao, C, Xiao, P, Shen, Q, Zhong, Y, Yang, F, Shen, D, Tao, X, Zhang, H, Yan, X, Zhao, R, He, J, Guan, Y, Zhang, C, Hou, G, Zhang, P, Yu, X, Guan, Y, Sun, J, Zhang, Y. | 登録日 | 2020-09-01 | 公開日 | 2021-05-05 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype. Sci Adv, 7, 2021
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