1X25
 
 | | Crystal Structure of a Member of YjgF Family from Sulfolobus Tokodaii (ST0811) | | Descriptor: | Hypothetical UPF0076 protein ST0811 | | Authors: | Miyakawa, T, Lee, W.C, Hatano, K, Kato, Y, Sawano, Y, Miyazono, K, Nagata, K, Tanokura, M. | | Deposit date: | 2005-04-20 | | Release date: | 2006-02-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the YjgF/YER057c/UK114 family protein from the hyperthermophilic archaeon Sulfolobus tokodaii strain 7
Proteins, 62, 2006
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5XPA
 | | Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 9'U10' on the target strand | | Descriptor: | DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), MAGNESIUM ION, RNA (5'-R(P*AP*UP*AP*CP*AP*AP*CP*CP*GP*UP*UP*CP*UP*AP*CP*UP*CP*CP*G)-3'), ... | | Authors: | Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, J.D, Wang, Y. | | Deposit date: | 2017-06-01 | | Release date: | 2018-04-18 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
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5XWP
 | | Crystal structure of LbuCas13a-crRNA-target RNA ternary complex | | Descriptor: | RNA (30-MER), RNA (59-MER), Uncharacterized protein | | Authors: | Liu, L, Li, X, Li, Z, Wang, Y. | | Deposit date: | 2017-06-30 | | Release date: | 2017-09-13 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (3.086 Å) | | Cite: | The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a.
Cell, 170, 2017
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5XPG
 | | Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 6'U7' on the target strand | | Descriptor: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*A P*GP*T)-3', 5'-R(*UP*AP*U*AP*CP*AP*AP*CP*CP*UP*AP*CP*AP*UP*AP*CP*CP*UP*CP* G)-3', MAGNESIUM ION, ... | | Authors: | Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, J.D, Wang, Y. | | Deposit date: | 2017-06-02 | | Release date: | 2018-04-18 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Nucleic Acids Res., 45, 2017
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8HNW
 | | Crystal structure of HpaCas9-sgRNA surveillance complex bound to double-stranded DNA | | Descriptor: | CRISPR-associated endonuclease Cas9, Non-target strand, Target strand, ... | | Authors: | Sun, W, Cheng, Z, Wang, Y. | | Deposit date: | 2022-12-08 | | Release date: | 2023-07-19 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.41 Å) | | Cite: | AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8HNS
 | | Crystal structure of an anti-CRISPR protein AcrIIC4 in apo form | | Descriptor: | GLYCEROL, anti-CRISPR protein AcrIIC4 | | Authors: | Sun, W, Cheng, Z, Yang, J, Wang, Y. | | Deposit date: | 2022-12-08 | | Release date: | 2023-07-19 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8HNT
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8H0O
 | | Crystal structure of human serum albumin and ruthenium PZA complex adduct | | Descriptor: | Albumin, CHLORIDE ION, NITRIC OXIDE, ... | | Authors: | Gong, W.J, Wang, Y, Bai, H.H, Wang, W.M, Wang, H.F. | | Deposit date: | 2022-09-30 | | Release date: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.479 Å) | | Cite: | Crystal structure of human serum albumin and ruthenium PZA complex adduct
To Be Published
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6JXR
 | | Structure of human T cell receptor-CD3 complex | | Descriptor: | T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, T-cell surface glycoprotein CD3 delta chain, ... | | Authors: | Dong, D, Zheng, L, Lin, J, Zhu, Y, Li, N, Zhang, B, Xie, S, Zheng, J, Wang, Y, Gao, N, Huang, Z. | | Deposit date: | 2019-04-24 | | Release date: | 2019-09-11 | | Last modified: | 2020-09-16 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural basis of assembly of the human T cell receptor-CD3 complex.
Nature, 573, 2019
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6IFO
 | | Crystal structure of AcrIIA2-SpyCas9-sgRNA ternary complex | | Descriptor: | AcrIIA2, CRISPR-associated endonuclease Cas9/Csn1, RNA (99-MER) | | Authors: | Liu, L, Wang, Y. | | Deposit date: | 2018-09-20 | | Release date: | 2019-01-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.313 Å) | | Cite: | Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race.
Mol. Cell, 73, 2019
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3KMX
 | | Structure of BACE bound to SCH346572 | | Descriptor: | 4-butoxy-3-chlorobenzyl imidothiocarbamate, Beta-secretase 1 | | Authors: | Strickland, C, Wang, Y. | | Deposit date: | 2009-11-11 | | Release date: | 2010-01-19 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors.
J.Med.Chem., 53, 2010
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3KN0
 | | Structure of BACE bound to SCH708236 | | Descriptor: | 3-[2-(3-{[(furan-2-ylmethyl)(methyl)amino]methyl}phenyl)ethyl]pyridin-2-amine, Beta-secretase 1, L(+)-TARTARIC ACID | | Authors: | Strickland, C, Wang, Y. | | Deposit date: | 2009-11-11 | | Release date: | 2010-01-19 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors.
J.Med.Chem., 53, 2010
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6K3Z
 | | Crystal structure of dCas9 in complex with sgRNA and DNA (TGA PAM) | | Descriptor: | CRISPR-associated endonuclease Cas9, DNA (28-MER), DNA (5'-D(*AP*AP*AP*TP*GP*AP*TP*AP*TP*TP*G)-3'), ... | | Authors: | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | Deposit date: | 2019-05-22 | | Release date: | 2019-09-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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6K4P
 | | Crystal structure of xCas9 in complex with sgRNA and DNA (TGG PAM) | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), PHOSPHATE ION, ... | | Authors: | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | Deposit date: | 2019-05-25 | | Release date: | 2019-09-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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6K4U
 | | Crystal structure of xCas9 in complex with sgRNA and DNA (TGA PAM) | | Descriptor: | CRISPR-associated endonuclease Cas9, non-target DNA, sgRNA, ... | | Authors: | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | Deposit date: | 2019-05-27 | | Release date: | 2019-09-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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5WTK
 | | Crystal structure of RNP complex | | Descriptor: | CRISPR-associated endoribonuclease C2c2, RNA (58-MER) | | Authors: | Liu, L, Wang, Y. | | Deposit date: | 2016-12-13 | | Release date: | 2017-02-08 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.651 Å) | | Cite: | Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
Cell, 168, 2017
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6KH4
 | | Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes | | Descriptor: | FE (III) ION, Ferritin, NICKEL (II) ION | | Authors: | Gu, C, Chen, H, Wang, Y, Zhang, T, Wang, H, Zhao, G. | | Deposit date: | 2019-07-12 | | Release date: | 2020-01-29 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.302 Å) | | Cite: | Structural Insight into Binary Protein Metal-Organic Frameworks with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes.
Chemistry, 26, 2020
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2CWV
 | | Product schiff-base intermediate of copper amine oxidase from arthrobacter globiformis | | Descriptor: | COPPER (II) ION, Phenylethylamine oxidase | | Authors: | Chiu, Y.C, Okajima, T, Murakawa, T, Uchida, M, Taki, M, Hirota, S, Kim, M, Yamaguchi, H, Kawano, Y, Kamiya, N, Kuroda, S, Hayashi, H, Yamamoto, Y, Tanizawa, K. | | Deposit date: | 2005-06-26 | | Release date: | 2006-05-02 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase(,)
Biochemistry, 45, 2006
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2CWU
 | | Substrate schiff-base intermediate of copper amine oxidase from arthrobacter globiformis | | Descriptor: | COPPER (II) ION, Phenylethylamine oxidase | | Authors: | Chiu, Y.C, Okajima, T, Murakawa, T, Uchida, M, Taki, M, Hirota, S, Kim, M, Yamaguchi, H, Kawano, Y, Kamiya, N, Kuroda, S, Hayashi, H, Yamamoto, Y, Tanizawa, K. | | Deposit date: | 2005-06-26 | | Release date: | 2006-05-02 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase(,)
Biochemistry, 45, 2006
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2CWT
 | | Catalytic base deletion in copper amine oxidase from arthrobacter globiformis | | Descriptor: | COPPER (II) ION, Phenylethylamine oxidase | | Authors: | Chiu, Y.C, Okajima, T, Murakawa, T, Uchida, M, Taki, M, Hirota, S, Kim, M, Yamaguchi, H, Kawano, Y, Kamiya, N, Kuroda, S, Hayashi, H, Yamamoto, Y, Tanizawa, K. | | Deposit date: | 2005-06-26 | | Release date: | 2006-05-02 | | Last modified: | 2021-11-10 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase(,)
Biochemistry, 45, 2006
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5XOU
 | | Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 7T8 on the guide strand | | Descriptor: | DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*TP*GP*GP*TP*TP*GP*T)-3'), MAGNESIUM ION, ... | | Authors: | Sheng, G, Wang, J, Zhao, H, Wang, Y. | | Deposit date: | 2017-05-31 | | Release date: | 2017-10-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
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5WTJ
 | | Crystal structure of an endonuclease | | Descriptor: | CRISPR-associated endoribonuclease C2c2 | | Authors: | Liu, L, Wang, Y. | | Deposit date: | 2016-12-13 | | Release date: | 2017-02-08 | | Last modified: | 2017-08-30 | | Method: | X-RAY DIFFRACTION (3.503 Å) | | Cite: | Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities
Cell, 168, 2017
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6K4Q
 | | Crystal structure of xCas9 in complex with sgRNA and DNA (CGG PAM) | | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), DNA (5'-D(*AP*AP*AP*CP*GP*GP*TP*AP*TP*TP*G)-3'), ... | | Authors: | Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q. | | Deposit date: | 2019-05-26 | | Release date: | 2019-09-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
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7CE2
 | | The Crystal structure of TeNT Hc complexed with neutralizing antibody | | Descriptor: | Tetanus toxin, neutralizing antibody heavy chain, neutralizing antibody light chain | | Authors: | Wang, X, Wang, Y, Wu, C, Yu, J, Liao, H. | | Deposit date: | 2020-06-21 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Structural basis of tetanus toxin neutralization by native human monoclonal antibodies.
Cell Rep, 35, 2021
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6KH3
 | | Design and crystal structure of protein MOFs with ferritin nanocages as linkers and nickel clusters as nodes | | Descriptor: | FE (III) ION, Ferritin, NICKEL (II) ION | | Authors: | Gu, C, Chen, H, Wang, Y, Zhang, T, Wang, H, Zhao, G. | | Deposit date: | 2019-07-12 | | Release date: | 2020-01-29 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Insight into Binary Protein Metal-Organic Frameworks with Ferritin Nanocages as Linkers and Nickel Clusters as Nodes.
Chemistry, 26, 2020
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