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6K3Z

Crystal structure of dCas9 in complex with sgRNA and DNA (TGA PAM)

Summary for 6K3Z
Entry DOI10.2210/pdb6k3z/pdb
DescriptorRNA (81-MER), CRISPR-associated endonuclease Cas9, DNA (28-MER), ... (4 entities in total)
Functional Keywordsendonuclease, hydrolase-dna-rna complex, hydrolase/dna/rna
Biological sourceStreptococcus pyogenes serotype M1
More
Total number of polymer chains4
Total formula weight197654.80
Authors
Chen, W.,Zhang, H.,Zhang, Y.,Wang, Y.,Gan, J.,Ji, Q. (deposition date: 2019-05-22, release date: 2019-09-25, Last modification date: 2023-11-22)
Primary citationChen, W.,Zhang, H.,Zhang, Y.,Wang, Y.,Gan, J.,Ji, Q.
Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17:e3000496-e3000496, 2019
Cited by
PubMed: 31603896
DOI: 10.1371/journal.pbio.3000496
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

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