2AX1
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![BU of 2ax1 by Molmil](/molmil-images/mine/2ax1) | Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5ee) | 分子名称: | 5R-(3,4-DICHLOROPHENYLMETHYL)-3-(2-THIOPHENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | 著者 | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | 登録日 | 2005-09-02 | 公開日 | 2006-01-24 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase. J.Med.Chem., 49, 2006
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7EMY
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7EN1
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![BU of 7en1 by Molmil](/molmil-images/mine/7en1) | Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module-after-condensation | 分子名称: | (4S)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid, 2-HYDROXYBENZOIC ACID, 4'-PHOSPHOPANTETHEINE, ... | 著者 | Wang, J.L, Wang, Z.J. | 登録日 | 2021-04-15 | 公開日 | 2021-12-22 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain. Nat Commun, 13, 2022
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7EN2
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3B4R
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![BU of 3b4r by Molmil](/molmil-images/mine/3b4r) | Site-2 Protease from Methanocaldococcus jannaschii | 分子名称: | Putative zinc metalloprotease MJ0392, ZINC ION | 著者 | Jeffrey, P.D, Feng, L, Yan, H, Wu, Z, Yan, N, Wang, Z, Shi, Y. | 登録日 | 2007-10-24 | 公開日 | 2008-01-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of a site-2 protease family intramembrane metalloprotease. Science, 318, 2007
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2AX0
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![BU of 2ax0 by Molmil](/molmil-images/mine/2ax0) | Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x) | 分子名称: | 5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | 著者 | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | 登録日 | 2005-09-02 | 公開日 | 2006-01-24 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase. J.Med.Chem., 49, 2006
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2AWZ
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![BU of 2awz by Molmil](/molmil-images/mine/2awz) | Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h) | 分子名称: | 5R-(4-BROMOPHENYLMETHYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | 著者 | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | 登録日 | 2005-09-02 | 公開日 | 2006-01-24 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase. J.Med.Chem., 49, 2006
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5XE0
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![BU of 5xe0 by Molmil](/molmil-images/mine/5xe0) | Crystal structure of EV-D68-3Dpol in complex with GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Genome polyprotein | 著者 | Xie, W, Wang, C, Wang, Z, Li, Q, Wang, C. | 登録日 | 2017-03-30 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure and Thermostability Characterization of Enterovirus D68 3Dpol J. Virol., 91, 2017
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3GYU
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![BU of 3gyu by Molmil](/molmil-images/mine/3gyu) | Nuclear receptor DAF-12 from parasitic nematode Strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 7 | 分子名称: | (5beta,14beta,17alpha,25R)-3-oxocholest-7-en-26-oic acid, Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily, SRC1 | 著者 | Zhou, X.E, Wang, Z, Suino-Powell, K, Motola, D.L, Conneely, A, Ogata, C, Sharma, K.K, Auchus, R.J, Kliewer, S.A, Xu, H.E, Mangelsdorf, D.J. | 登録日 | 2009-04-05 | 公開日 | 2009-07-07 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proc.Natl.Acad.Sci.USA, 106, 2009
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6IUG
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![BU of 6iug by Molmil](/molmil-images/mine/6iug) | Cryo-EM structure of the plant actin filaments from Zea mays pollen | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, pollen F-actin | 著者 | Ren, Z.H, Zhang, Y, Zhang, Y, He, Y.Q, Du, P.Z, Wang, Z.X, Sun, F, Ren, H.Y. | 登録日 | 2018-11-28 | 公開日 | 2019-11-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM Structure of Actin Filaments fromZea maysPollen. Plant Cell, 31, 2019
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4L02
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![BU of 4l02 by Molmil](/molmil-images/mine/4l02) | Crystal Structure of SphK1 with inhibitor | 分子名称: | (2R,4S)-1-[2-(4-{[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]amino}phenyl)ethyl]-2-(hydroxymethyl)piperidin-4-ol, Sphingosine kinase 1 | 著者 | Min, X, Walker, N, Wang, Z. | 登録日 | 2013-05-30 | 公開日 | 2013-07-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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5X8Y
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![BU of 5x8y by Molmil](/molmil-images/mine/5x8y) | A Mutation identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in vitro | 分子名称: | ZIKV NS1 | 著者 | Wang, D, Chen, C, Liu, S, Zhou, H, Yang, K, Zhao, Q, Ji, X, Chen, C, Xie, W, Wang, Z, Mi, L.Z, Yang, H. | 登録日 | 2017-03-03 | 公開日 | 2017-05-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.817 Å) | 主引用文献 | A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro Sci Rep, 7, 2017
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4DUM
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![BU of 4dum by Molmil](/molmil-images/mine/4dum) | Co-crystal structure of eIF4E with inhibitor | 分子名称: | (4-{7-[2-(4-chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl}phenyl)phosphonic acid, 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 4E | 著者 | Min, X, Johnstone, S, Walker, N, Wang, Z. | 登録日 | 2012-02-22 | 公開日 | 2012-04-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction. J.Med.Chem., 55, 2012
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4DN5
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![BU of 4dn5 by Molmil](/molmil-images/mine/4dn5) | Crystal Structure of NF-kB-inducing Kinase (NIK) | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, MAGNESIUM ION, ... | 著者 | Min, X, Liu, J, Sudom, A, Walker, N.P, Wang, Z. | 登録日 | 2012-02-08 | 公開日 | 2012-06-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of Nuclear Factor Kappa B-inducing kinase domain reveals a constitutively active conformation J.Biol.Chem., 287, 2012
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5WT9
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![BU of 5wt9 by Molmil](/molmil-images/mine/5wt9) | Complex structure of PD-1 and nivolumab-Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Nivolumab, Light Chain of Nivolumab, ... | 著者 | Tan, S, Zhang, H, Chai, Y, Song, H, Tong, Z, Wang, Q, Qi, J, Wong, G, Zhu, X, Liu, W.J, Gao, S, Wang, Z, Shi, Y, Yang, F, Gao, G.F, Yan, J. | 登録日 | 2016-12-10 | 公開日 | 2017-02-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. Nat Commun, 8, 2017
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3JAV
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![BU of 3jav by Molmil](/molmil-images/mine/3jav) | Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM | 分子名称: | Inositol 1,4,5-trisphosphate receptor type 1 | 著者 | Fan, G, Baker, M.L, Wang, Z, Baker, M.R, Sinyagovskiy, P.A, Chiu, W, Ludtke, S.J, Serysheva, I.I. | 登録日 | 2015-06-30 | 公開日 | 2015-10-07 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Nature, 527, 2015
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6ITP
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![BU of 6itp by Molmil](/molmil-images/mine/6itp) | Crystal structure of cortisol complexed with its nanobody at pH 3.5 | 分子名称: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, anti-cortisol camelid antibody | 著者 | Ding, Y, Ding, L.L, Wang, Z.Y, Zhong, P.Y. | 登録日 | 2018-11-24 | 公開日 | 2019-07-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.572 Å) | 主引用文献 | Structural insights into the mechanism of single domain VHH antibody binding to cortisol. Febs Lett., 593, 2019
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6ITQ
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![BU of 6itq by Molmil](/molmil-images/mine/6itq) | Crystal structure of cortisol complexed with its nanobody at pH 10.5 | 分子名称: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, SULFATE ION, anti-cortisol camelid antibody | 著者 | Ding, Y, Ding, L.L, Wang, Z.Y, Zhong, P.Y. | 登録日 | 2018-11-24 | 公開日 | 2019-07-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.526 Å) | 主引用文献 | Structural insights into the mechanism of single domain VHH antibody binding to cortisol. Febs Lett., 593, 2019
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3FXV
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![BU of 3fxv by Molmil](/molmil-images/mine/3fxv) | Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist | 分子名称: | 12-meric peptide from Nuclear receptor coactivator 1, 6-(4-{[3-(3,5-dichloropyridin-4-yl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-2-methylphenyl)-1-methyl-1H-indole-3-carbox ylic acid, NR1H4 protein | 著者 | Feng, S, Yang, M, He, Y, Chen, L, Zhang, Z, Wang, Z, Hong, D, Richter, H, Benson, G.M, Bleicher, K, Grether, U, Martin, R, Plancher, J.-M, Kuhn, B, Rudolph, M.G. | 登録日 | 2009-01-21 | 公開日 | 2009-04-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist Bioorg.Med.Chem.Lett., 19, 2009
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8JZN
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![BU of 8jzn by Molmil](/molmil-images/mine/8jzn) | Structure of a fungal 1,3-beta-glucan synthase | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,3-beta-glucan synthase component FKS1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, C, You, Z, Chen, D, Hang, J, Wang, Z, Meng, J, Wang, L, Zhao, P, Qiao, J, Yun, C, Bai, L. | 登録日 | 2023-07-05 | 公開日 | 2023-10-04 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.47 Å) | 主引用文献 | Structure of a fungal 1,3-beta-glucan synthase. Sci Adv, 9, 2023
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4DT6
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![BU of 4dt6 by Molmil](/molmil-images/mine/4dt6) | Co-crystal structure of eIF4E with inhibitor | 分子名称: | 1,2-ETHANEDIOL, 7-[2-(4-chlorophenoxy)ethyl]guanosine 5'-(dihydrogen phosphate), Eukaryotic translation initiation factor 4E, ... | 著者 | Min, X, Johnstone, S, Walker, N, Wang, Z. | 登録日 | 2012-02-20 | 公開日 | 2012-04-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction. J.Med.Chem., 55, 2012
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5UJV
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![BU of 5ujv by Molmil](/molmil-images/mine/5ujv) | Crystal structure of FePYR1 in complex with abscisic acid | 分子名称: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, PYR1 | 著者 | Ren, Z, Wang, Z, Zhou, X.E, Hong, Y, Cao, M, Chan, Z, Liu, X, Shi, H, Xu, H.E, Zhu, J.-K. | 登録日 | 2017-01-19 | 公開日 | 2017-11-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure determination and activity manipulation of the turfgrass ABA receptor FePYR1. Sci Rep, 7, 2017
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3GYT
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![BU of 3gyt by Molmil](/molmil-images/mine/3gyt) | Nuclear receptor DAF-12 from parasitic nematode Strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 4 | 分子名称: | (14beta,17alpha,25R)-3-oxocholest-4-en-26-oic acid, Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily, SRC1 | 著者 | Zhou, X.E, Wang, Z, Suino-Powell, K, Motola, D.L, Conneely, A, Ogata, C, Sharma, K.K, Auchus, R.J, Kliewer, S.A, Xu, H.E, Mangelsdorf, D.J. | 登録日 | 2009-04-05 | 公開日 | 2009-07-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes. Proc.Natl.Acad.Sci.USA, 106, 2009
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6CXC
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![BU of 6cxc by Molmil](/molmil-images/mine/6cxc) | 3.9A Cryo-EM structure of murine antibody bound at a novel epitope of respiratory syncytial virus fusion protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, Envelope glycoprotein chimera, ... | 著者 | Xie, Q, Wang, Z, Chen, X, Ni, F, Ma, J, Wang, Q. | 登録日 | 2018-04-02 | 公開日 | 2019-07-31 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure basis of neutralization by a novel site II/IV antibody against respiratory syncytial virus fusion protein. Plos One, 14, 2019
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7XSC
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![BU of 7xsc by Molmil](/molmil-images/mine/7xsc) | |