6ITQ
Crystal structure of cortisol complexed with its nanobody at pH 10.5
Summary for 6ITQ
| Entry DOI | 10.2210/pdb6itq/pdb |
| Descriptor | anti-cortisol camelid antibody, (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | cortisol, complex, nanobody, camelid antibody, immune system |
| Biological source | Camelus bactrianus |
| Total number of polymer chains | 4 |
| Total formula weight | 56762.35 |
| Authors | Ding, Y.,Ding, L.L.,Wang, Z.Y.,Zhong, P.Y. (deposition date: 2018-11-24, release date: 2019-07-24, Last modification date: 2023-11-22) |
| Primary citation | Ding, L.,Wang, Z.,Zhong, P.,Jiang, H.,Zhao, Z.,Zhang, Y.,Ren, Z.,Ding, Y. Structural insights into the mechanism of single domain VHH antibody binding to cortisol. Febs Lett., 593:1248-1256, 2019 Cited by PubMed: 31049949DOI: 10.1002/1873-3468.13398 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.526 Å) |
Structure validation
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