3FXV

Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist

Summary for 3FXV

• Entry DOI: 10.2210/pdb3fxv/pdb
• Descriptor: NR1H4 protein, 12-meric peptide from Nuclear receptor coactivator 1, 6-(4-{[3-(3,5-dichloropyridin-4-yl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-2-methylphenyl)-1-methyl-1H-indole-3-carbox ylic acid, ... (4 entities in total)
• Functional Keywords: nuclear receptor, cholesterol, bile acid, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger, activator, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, hormone receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : Q15788
• Total number of polymer chains: 2
• Total formula weight: 29311.53

Authors

Feng, S.,Yang, M.,He, Y.,Chen, L.,Zhang, Z.,Wang, Z.,Hong, D.,Richter, H.,Benson, G.M.,Bleicher, K.,Grether, U.,Martin, R.,Plancher, J.-M.,Kuhn, B.,Rudolph, M.G. (deposition date: 2009-01-21, release date: 2009-04-14, Last modification date: 2024-04-03)

• Primary citation: Feng, S.,Yang, M.,Zhang, Z.,Wang, Z.,Hong, D.,Richter, H.,Benson, G.M.,Bleicher, K.,Grether, U.,Martin, R.E.,Plancher, J.-M.,Kuhn, B.,Rudolph, M.G.,Chen, L.; Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist; Bioorg.Med.Chem.Lett., 19:2595-2598, 2009; PubMed: 19328688; DOI: 10.1016/j.bmcl.2009.03.008

Experimental method

X-RAY DIFFRACTION (2.26 Å)