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PDB: 116 件
1LTI
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HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN
分子名称: HEAT LABILE ENTEROTOXIN TYPE I, beta-D-galactopyranose, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose
著者Van Den Akker, F, Hol, W.G.J.
登録日1996-05-09
公開日1996-08-17
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli.
Protein Sci., 5, 1996
1TII
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ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB
分子名称: HEAT LABILE ENTEROTOXIN TYPE IIB
著者Van Den Akker, F, Hol, W.G.J.
登録日1996-03-20
公開日1996-08-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal structure of a new heat-labile enterotoxin, LT-IIb.
Structure, 4, 1996
2H10
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Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to tazobactam
分子名称: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, TAZOBACTAM INTERMEDIATE
著者van den Akker, F, Padayatti, P.S.
登録日2006-05-15
公開日2007-01-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates.
Biochemistry, 45, 2006
2H0Y
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Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to sulbactam
分子名称: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ETHANESULFONIC ACID, ...
著者van den Akker, F, Padayatti, P.S.
登録日2006-05-15
公開日2007-01-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates.
Biochemistry, 45, 2006
2H5S
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SA2-13 penam sulfone complexed to wt SHV-1 beta-lactamase
分子名称: (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, SHV-1 beta-lactamase
著者van den Akker, F, Padayatti, P.S.
登録日2006-05-27
公開日2006-10-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Rational Design of a beta-Lactamase Inhibitor Achieved via Stabilization of the trans-Enamine Intermediate: 1.28 A Crystal Structure of wt SHV-1 Complex with a Penam Sulfone.
J.Am.Chem.Soc., 128, 2006
1DP4
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DIMERIZED HORMONE BINDING DOMAIN OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATRIAL NATRIURETIC PEPTIDE RECEPTOR A, ...
著者van den Akker, F, Zhang, X, Miyagi, M, Huo, X, Misono, K.S, Yee, V.C.
登録日1999-12-23
公開日2000-07-12
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor.
Nature, 406, 2000
3V5M
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Crystal structure of M69V mutant of SHV beta-lactamase
分子名称: Beta-lactamase, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者van den Akker, F, Rodkey, E.A.
登録日2011-12-16
公開日2012-08-08
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The importance of the trans-enamine intermediate as a beta-lactamase inhibition strategy probed in inhibitor-resistant SHV beta-lactamase variants.
Chemmedchem, 7, 2012
2P08
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Structure of the N-terminally truncated PAS domain of signal transduction histidine kinase from Nostoc punctiforme PCC 73102 with homology to the H-NOXA/H-NOBA domain of the soluble guanylyl cyclase
分子名称: SULFATE ION, signal transduction histidine kinase
著者van den Akker, F, Ma, X.
登録日2007-02-28
公開日2007-11-13
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure.
J.Biol.Chem., 283, 2008
2P04
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2.1 Ang structure of the dimerized PAS domain of signal transduction histidine kinase from Nostoc punctiforme PCC 73102 with homology to the H-NOXA/H-NOBA domain of the soluble guanylyl cyclase
分子名称: signal transduction histidine kinase
著者van den Akker, F, Ma, X.
登録日2007-02-28
公開日2007-11-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure.
J.Biol.Chem., 283, 2008
4DXB
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2.29A structure of the engineered MBP TEM-1 fusion protein RG13 in complex with zinc, P1 space group
分子名称: Maltose-binding periplasmic protein, Beta-lactamase TEM chimera, ZINC ION
著者van den Akker, F, Ke, W.
登録日2012-02-27
公開日2012-08-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Structure of an Engineered beta-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation.
Plos One, 7, 2012
4DXC
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Crystal structure of the engineered MBP TEM-1 fusion protein RG13, C2 space group
分子名称: Maltose-binding periplasmic protein, Beta-lactamase TEM chimera, ZINC ION
著者van den Akker, F, Ke, W.
登録日2012-02-27
公開日2012-08-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of an Engineered beta-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation.
Plos One, 7, 2012
4GD6
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SHV-1 beta-lactamase in complex with penam sulfone SA1-204
分子名称: (3R)-N-(2-formylindolizin-3-yl)-4-[(phenylacetyl)oxy]-3-sulfino-D-valine, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者van den Akker, F, Wei, K.
登録日2012-07-31
公開日2013-07-31
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation
Plos One, 7, 2012
3D4F
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SHV-1 beta-lactamase complex with LN1-255
分子名称: (3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Pattanaik, P, Bethel, C.R, Hujer, A.M, Bonomo, R.A, Buynak, J.D, van den Akker, F.
登録日2008-05-14
公開日2009-02-10
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Strategic Design of an Effective {beta}-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE
J.Biol.Chem., 284, 2009
4GDB
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SHV-1 in complex with 4H-pyrazolo[1,5-c][1,3]thiazole containing penem inhibitor
分子名称: (7R)-6-formyl-7-(4H-pyrazolo[1,5-c][1,3]thiazol-2-yl)-4,7-dihydro-1,4-thiazepine-3-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase SHV-1, ...
著者Ke, W, van den Akker, F.
登録日2012-07-31
公開日2013-07-31
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation
Plos One, 7, 2012
4GD8
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SHV-1 beta-lactamase in complex with penam sulfone SA3-53
分子名称: (2S,3R)-4-(2-aminoethylcarbamoyloxy)-2-[(2-methanoylindolizin-3-yl)amino]-3-methyl-3-sulfino-butanoic acid, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Pattanaik, P, van den Akker, F.
登録日2012-07-31
公開日2013-07-31
最終更新日2013-08-07
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation
Plos One, 7, 2012
5IXX
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BU of 5ixx by Molmil
Crystal structure of the signaling protein complex 4
分子名称: 1-(1H-imidazol-1-yl)ethan-1-one, Alr2278 protein, MALONATE ION, ...
著者Kumar, V, van den Akker, F.
登録日2016-03-23
公開日2017-08-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of the signaling protein complex 4
To Be Published
5IXR
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Crystal Structure of C139A nostoc H-NOX domain with imidazole
分子名称: Alr2278 protein, IMIDAZOLE, MALONATE ION, ...
著者Kumar, V, van den Akker, F.
登録日2016-03-23
公開日2017-08-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of C139A nostoc H-NOX domain with imidazole
To Be Published
5IXV
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Crystal structure of the signaling protein complex 2
分子名称: 1-METHYLIMIDAZOLE, Alr2278 protein, MALONATE ION, ...
著者Kumar, V, van den Akker, F.
登録日2016-03-23
公開日2017-08-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the signaling protein complex 2
To Be Published
5IXZ
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Crystal structure of the signaling protein complex 5
分子名称: Alr2278 protein, DIMETHYL SULFOXIDE, MALONATE ION, ...
著者Kumar, V, van den Akker, F.
登録日2016-03-23
公開日2017-11-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the signaling protein complex 5
To Be Published
5IXW
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Crystal structure of the signaling protein complex 3
分子名称: 1-VINYLIMIDAZOLE, Alr2278 protein, MALONATE ION, ...
著者Kumar, V, van den Akker, F.
登録日2016-03-23
公開日2017-08-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Crystal structure of the signaling protein complex 3
To Be Published
4ZAM
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Crystal structure of SHV-1 beta-lactamase bound to avibactam
分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Krishnan, N, van den Akker, F.
登録日2015-04-13
公開日2016-01-27
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Inhibition of Klebsiella beta-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study.
Plos One, 10, 2015
4ZBE
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Crystal structure of KPC-2 beta-lactamase complexed with avibactam
分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, CITRIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC
著者Nguyen, N.Q, van den Akker, F.
登録日2015-04-14
公開日2016-01-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Inhibition of Klebsiella beta-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study.
Plos One, 10, 2015
4R3B
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Crystal structure of SHV-1 b-lactamase in complex with 6b-(hydroxymethyl)penicillanic acid sulfone PSR-283A
分子名称: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, N-[(1E)-2-formyl-3-hydroxyprop-1-en-1-yl]-3-[(S)-sulfino]-D-valine
著者Rodkey, E.A, van den Akker, F.
登録日2014-08-14
公開日2015-01-21
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.366 Å)
主引用文献Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV-1 beta-Lactamase and 6 beta-(Hydroxymethyl)penicillanic Acid Sulfone.
Biochemistry, 54, 2015
8SDV
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Crystal structure of PDC-3 Y221H beta-lactamase in complex with the boronic acid inhibitor S02030
分子名称: 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid, Beta-lactamase, DIMETHYL SULFOXIDE, ...
著者Kumar, V, van den Akker, F.
登録日2023-04-07
公開日2023-08-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Natural protein engineering in the Omega-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas -derived cephalosporinase.
Antimicrob.Agents Chemother., 67, 2023
8SDN
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Crystal structure of PDC-3 Y221H beta-lactamase
分子名称: Beta-lactamase, ISOPROPYL ALCOHOL
著者Kumar, V, van den Akker, F.
登録日2023-04-07
公開日2023-08-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Natural protein engineering in the Omega-loop: the role of Y221 in ceftazidime and ceftolozane resistance in Pseudomonas -derived cephalosporinase.
Antimicrob.Agents Chemother., 67, 2023

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件を2024-07-17に公開中

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