3RXX

KPC-2 carbapenemase in complex with 3-NPBA

Summary for 3RXX

• Entry DOI: 10.2210/pdb3rxx/pdb
• Related: 3QXW
• Descriptor: Carbepenem-hydrolyzing beta-lactamase KPC, 3-NITROPHENYLBORONIC ACID (3 entities in total)
• Functional Keywords: inhibitor, beta-lactamase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 28159.43

Authors

Ke, W.,van den Akker, F. (deposition date: 2011-05-10, release date: 2012-03-21, Last modification date: 2023-09-13)

• Primary citation: Ke, W.,Bethel, C.R.,Papp-Wallace, K.M.,Pagadala, S.R.,Nottingham, M.,Fernandez, D.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F.; Crystal structures of KPC-2 {beta}-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226.; Antimicrob.Agents Chemother., 56:2713-2718, 2012; PubMed: 22330909; DOI: 10.1128/AAC.06099-11

Experimental method

X-RAY DIFFRACTION (1.62 Å)