2H10

Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to tazobactam

Summary for 2H10

• Entry DOI: 10.2210/pdb2h10/pdb
• Related: 1RCJ 2A3U 2A49 2H0Y
• Descriptor: Beta-lactamase SHV-1, TAZOBACTAM INTERMEDIATE, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (4 entities in total)
• Functional Keywords: antibiotic resistance, b-lactamase inhibitor, hydrolase
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 30136.43

Authors

van den Akker, F.,Padayatti, P.S. (deposition date: 2006-05-15, release date: 2007-01-30, Last modification date: 2023-08-30)

• Primary citation: Totir, M.A.,Padayatti, P.S.,Helfand, M.S.,Carey, M.P.,Bonomo, R.A.,Carey, P.R.,van den Akker, F.; Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates.; Biochemistry, 45:11895-11904, 2006; PubMed: 17002290; DOI: 10.1021/bi060990m

Experimental method

X-RAY DIFFRACTION (1.75 Å)