2H10
Crystal structure of the M69V E166A double mutant of SHV-1 b-lactamase complexed to tazobactam
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-lactamase SHV-1 | polymer | 265 | 28816.9 | 1 | UniProt (P0AD64) Pfam (PF00144) Pfam (PF13354) | Klebsiella pneumoniae | PIT-2 |
| 2 | B (A) | TAZOBACTAM INTERMEDIATE | non-polymer | 302.3 | 1 | Chemie (TBE) | |||
| 3 | C, D (A) | CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | non-polymer | 508.6 | 2 | Chemie (MA4) | |||
| 4 | E (A) | water | water | 18.0 | 307 | Chemie (HOH) |
Sequence modifications
A: 26 - 290 (UniProt: P0AD64)
| PDB | External Database | Details |
|---|---|---|
| Val 69 | Met 65 | engineered mutation |
| Ala 166 | Glu 162 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28816.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1319.5 | |
| All* | Total formula weight | 30136.4 |
