Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 116 件
4ZBE
DownloadVisualize
BU of 4zbe by Molmil
Crystal structure of KPC-2 beta-lactamase complexed with avibactam
分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, CITRIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC
著者Nguyen, N.Q, van den Akker, F.
登録日2015-04-14
公開日2016-01-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Inhibition of Klebsiella beta-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study.
Plos One, 10, 2015
3HLS
DownloadVisualize
BU of 3hls by Molmil
Crystal structure of the signaling helix coiled-coil doimain of the BETA-1 subunit of the soluble guanylyl cyclase
分子名称: Guanylate cyclase soluble subunit beta-1
著者Ma, X, van den Akker, F.
登録日2009-05-28
公開日2010-01-19
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of the signaling helix coiled-coil domain of the beta-1 subunit of the soluble guanylyl cyclase.
Bmc Struct.Biol., 10, 2010
5EEC
DownloadVisualize
BU of 5eec by Molmil
Crystal structure of KPC-2 beta-lactamase in complex with the S02030 boronic acid inhibitor
分子名称: 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, SULFATE ION
著者Nguyen, N.Q, van den Akker, F.
登録日2015-10-22
公開日2016-02-03
最終更新日2016-03-09
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Crystal Structures of KPC-2 and SHV-1 beta-Lactamases in Complex with the Boronic Acid Transition State Analog S02030.
Antimicrob.Agents Chemother., 60, 2016
5IXX
DownloadVisualize
BU of 5ixx by Molmil
Crystal structure of the signaling protein complex 4
分子名称: 1-(1H-imidazol-1-yl)ethan-1-one, Alr2278 protein, MALONATE ION, ...
著者Kumar, V, van den Akker, F.
登録日2016-03-23
公開日2017-08-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of the signaling protein complex 4
To Be Published
5IXR
DownloadVisualize
BU of 5ixr by Molmil
Crystal Structure of C139A nostoc H-NOX domain with imidazole
分子名称: Alr2278 protein, IMIDAZOLE, MALONATE ION, ...
著者Kumar, V, van den Akker, F.
登録日2016-03-23
公開日2017-08-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of C139A nostoc H-NOX domain with imidazole
To Be Published
5IXW
DownloadVisualize
BU of 5ixw by Molmil
Crystal structure of the signaling protein complex 3
分子名称: 1-VINYLIMIDAZOLE, Alr2278 protein, MALONATE ION, ...
著者Kumar, V, van den Akker, F.
登録日2016-03-23
公開日2017-08-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Crystal structure of the signaling protein complex 3
To Be Published
5EE8
DownloadVisualize
BU of 5ee8 by Molmil
Crystal structure of S02030 boronic acid inhibitor complexed to SHV-1 beta-lactamase
分子名称: 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Krishnan, N, van den Akker, F.
登録日2015-10-22
公開日2016-01-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Crystal Structures of KPC-2 and SHV-1 beta-Lactamases in Complex with the Boronic Acid Transition State Analog S02030.
Antimicrob.Agents Chemother., 60, 2016
5IXV
DownloadVisualize
BU of 5ixv by Molmil
Crystal structure of the signaling protein complex 2
分子名称: 1-METHYLIMIDAZOLE, Alr2278 protein, MALONATE ION, ...
著者Kumar, V, van den Akker, F.
登録日2016-03-23
公開日2017-08-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the signaling protein complex 2
To Be Published
5IXZ
DownloadVisualize
BU of 5ixz by Molmil
Crystal structure of the signaling protein complex 5
分子名称: Alr2278 protein, DIMETHYL SULFOXIDE, MALONATE ION, ...
著者Kumar, V, van den Akker, F.
登録日2016-03-23
公開日2017-11-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the signaling protein complex 5
To Be Published
7KIS
DownloadVisualize
BU of 7kis by Molmil
Crystal structure of Pseudomonas aeruginosa PBP2 in complex with WCK 5153
分子名称: (2S,5R)-1-formyl-N'-[(3R)-pyrrolidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, CHLORIDE ION, Peptidoglycan D,D-transpeptidase MrdA
著者Rajavel, M, van den Akker, F.
登録日2020-10-24
公開日2021-01-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.869 Å)
主引用文献Structural Characterization of Diazabicyclooctane beta-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa.
Mbio, 12, 2021
4MBK
DownloadVisualize
BU of 4mbk by Molmil
Crystal structure of K234R inhibitor-resistant variant of SHV beta-lactamase in complex with SA2-13
分子名称: (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Rodkey, E.A, van den Akker, F.
登録日2013-08-19
公開日2014-07-30
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Penam sulfones and beta-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.
Plos One, 9, 2014
4MBH
DownloadVisualize
BU of 4mbh by Molmil
Penam sulfone PSR-3-226 bound to E166A variant of SHV-1 beta-lactamase
分子名称: 3-(formylamino)-L-alanine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase SHV-1, ...
著者Rodkey, E.A, van den Akker, F.
登録日2013-08-19
公開日2014-07-30
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.22 Å)
主引用文献Penam sulfones and beta-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.
Plos One, 9, 2014
4MBF
DownloadVisualize
BU of 4mbf by Molmil
Crystal structure of Penam sulfone PSR-4-157 bound to SHV-1 beta-lactamase
分子名称: 6-({(2R,3S)-3-carboxy-2-methyl-3-[(3-oxopropyl)amino]-2-sulfinopropyl}oxy)-6-oxohexanoic acid, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Rodkey, E.A, van den Akker, F.
登録日2013-08-19
公開日2014-07-30
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Penam sulfones and beta-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.
Plos One, 9, 2014
4R3B
DownloadVisualize
BU of 4r3b by Molmil
Crystal structure of SHV-1 b-lactamase in complex with 6b-(hydroxymethyl)penicillanic acid sulfone PSR-283A
分子名称: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, N-[(1E)-2-formyl-3-hydroxyprop-1-en-1-yl]-3-[(S)-sulfino]-D-valine
著者Rodkey, E.A, van den Akker, F.
登録日2014-08-14
公開日2015-01-21
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.366 Å)
主引用文献Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV-1 beta-Lactamase and 6 beta-(Hydroxymethyl)penicillanic Acid Sulfone.
Biochemistry, 54, 2015
3V50
DownloadVisualize
BU of 3v50 by Molmil
Complex of SHV S130G mutant beta-lactamase complexed to SA2-13
分子名称: (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, Beta-lactamase, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Wei, K, van den Akker, F.
登録日2011-12-15
公開日2012-08-08
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The importance of the trans-enamine intermediate as a beta-lactamase inhibition strategy probed in inhibitor-resistant SHV beta-lactamase variants.
Chemmedchem, 7, 2012
1RCJ
DownloadVisualize
BU of 1rcj by Molmil
Crystal structure of E166A mutant of SHV-1 beta-lactamase with the trans-enamine intermediate of tazobactam
分子名称: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, TAZOBACTAM TRANS-ENAMINE INTERMEDIATE
著者Padayatti, P.S, Helfand, M.S, Totir, M.A, Carey, M.P, Hujer, A.M, Carey, P.R, Bonomo, R.A, van den Akker, F.
登録日2003-11-04
公開日2004-02-17
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Tazobactam Forms a Stoichiometric trans-Enamine Intermediate in the E166A Variant of SHV-1 beta-Lactamase: 1.63 A Crystal Structure
Biochemistry, 43, 2004
3MXR
DownloadVisualize
BU of 3mxr by Molmil
SHV-1 beta-lactamase complex with compound 1
分子名称: ({[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-4-(4-hydroxyphenyl)butanoyl]amino}methyl)boronic acid, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Ke, W, van den Akker, F.
登録日2010-05-07
公開日2010-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors.
Antimicrob.Agents Chemother., 55, 2011
3MXS
DownloadVisualize
BU of 3mxs by Molmil
SHV-1 beta-lactamase complex with compound 2
分子名称: Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, N-[(dihydroxyboranyl)methyl]-Nalpha-[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]-D-tyrosinamide
著者Ke, W, van den Akker, F.
登録日2010-05-07
公開日2010-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors.
Antimicrob.Agents Chemother., 55, 2011
4IAE
DownloadVisualize
BU of 4iae by Molmil
Crystal structure of BAY 60-2770 bound to nostoc H-NOX domain
分子名称: 4-({(4-carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}methyl)benzoic acid, Alr2278 protein, MALONATE ION
著者Kumar, V, van den Akker, F, Martin, F.
登録日2012-12-06
公開日2013-11-20
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes.
Biochemistry, 52, 2013
3OPH
DownloadVisualize
BU of 3oph by Molmil
ESBL R164S mutant of SHV-1 beta-lactamase
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Sampson, J.M, van den Akker, F.
登録日2010-09-01
公開日2011-07-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
Antimicrob.Agents Chemother., 55, 2011
3MBZ
DownloadVisualize
BU of 3mbz by Molmil
OXA-24 beta-lactamase complex soaked with 10mM SA4-17 inhibitor for 15min
分子名称: (2S,3R)-2-[(7-aminocarbonyl-2-methanoyl-indolizin-3-yl)amino]-4-aminocarbonyloxy-3-methyl-3-sulfino-butanoic acid, Betalactamase OXA24, SULFATE ION
著者Sampson, J, van den Akker, F.
登録日2010-03-26
公開日2011-03-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase
J.Am.Chem.Soc., 132, 2010
3OPP
DownloadVisualize
BU of 3opp by Molmil
ESBL R164S mutant of SHV-1 beta-lactamase complexed with SA2-13
分子名称: (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Sampson, J.M, van den Akker, F.
登録日2010-09-01
公開日2011-07-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
Antimicrob.Agents Chemother., 55, 2011
4IAH
DownloadVisualize
BU of 4iah by Molmil
Crystal Structure of BAY 60-2770 bound C139A H-NOX domain with S-nitrosylated conserved C122
分子名称: 4-({(4-carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}methyl)benzoic acid, Alr2278 protein, MALONATE ION
著者Kumar, V, van den Akker, F.
登録日2012-12-06
公開日2013-11-20
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes.
Biochemistry, 52, 2013
3OPL
DownloadVisualize
BU of 3opl by Molmil
ESBL R164H mutant SHV-1 beta-lactamase
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Sampson, J.M, van den Akker, F.
登録日2010-09-01
公開日2011-07-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
Antimicrob.Agents Chemother., 55, 2011
3OPR
DownloadVisualize
BU of 3opr by Molmil
ESBL R164H mutant of SHV-1 beta-lactamase complexed to SA2-13
分子名称: (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE
著者Sampson, J.M, van den Akker, F.
登録日2010-09-01
公開日2011-07-13
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
Antimicrob.Agents Chemother., 55, 2011

224572

件を2024-09-04に公開中

PDB statisticsPDBj update infoContact PDBjnumon