3V50

Complex of SHV S130G mutant beta-lactamase complexed to SA2-13

Summary for 3V50

• Entry DOI: 10.2210/pdb3v50/pdb
• Related: 2H10 2H5S 3OPP 3OPR
• Descriptor: Beta-lactamase, (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (4 entities in total)
• Functional Keywords: class a beta-lactamase fold, hydrolyze b-lactam antibiotics, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 30259.55

Authors

Wei, K.,van den Akker, F. (deposition date: 2011-12-15, release date: 2012-08-08)

• Primary citation: Ke, W.,Rodkey, E.A.,Sampson, J.M.,Skalweit, M.J.,Sheri, A.,Pagadala, S.R.,Nottingham, M.D.,Buynak, J.D.,Bonomo, R.A.,van den Akker, F.; The importance of the trans-enamine intermediate as a beta-lactamase inhibition strategy probed in inhibitor-resistant SHV beta-lactamase variants.; Chemmedchem, 7:1002-1008, 2012; PubMed: 22438274; DOI: 10.1002/cmdc.201200006

Experimental method

X-RAY DIFFRACTION (1.45 Å)