5EEC

Crystal structure of KPC-2 beta-lactamase in complex with the S02030 boronic acid inhibitor

Summary for 5EEC

Entry DOI	10.2210/pdb5eec/pdb
Related	5EE8
Descriptor	Carbapenem-hydrolyzing beta-lactamase KPC, 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	transition state inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Klebsiella pneumoniae
Total number of polymer chains	2
Total formula weight	58232.77
Authors	Nguyen, N.Q.,van den Akker, F. (deposition date: 2015-10-22, release date: 2016-02-03, Last modification date: 2016-03-09)
Primary citation	Nguyen, N.Q.,Krishnan, N.P.,Rojas, L.J.,Prati, F.,Caselli, E.,Romagnoli, C.,Bonomo, R.A.,van den Akker, F. Crystal Structures of KPC-2 and SHV-1 beta-Lactamases in Complex with the Boronic Acid Transition State Analog S02030. Antimicrob.Agents Chemother., 60:1760-1766, 2016 Cited by PubMed: 26729491 DOI: 10.1128/AAC.02643-15 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation