SHV-1 beta-lactamase complex with compound 1

Summary for 3MXR
Related3MKE 3MKF 3MXS
DescriptorBeta-lactamase SHV-1, ({[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-4-(4-hydroxyphenyl)butanoyl]amino}methyl)boronic acid, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (4 entities in total)
Functional Keywordsbeta-lactamase, boronic acid transition state inhibitor, drug design, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceKlebsiella pneumoniae
Total number of polymer chains1
Total formula weight30344.44
Ke, W.,van den Akker, F. (deposition date: 2010-05-07, release date: 2010-11-24, Last modification date: 2017-11-08)
Primary citationBethel, C.R.,Bonomo, R.A.,Drawz, S.M.,Ke, W.,Ori, C.,Prati, F.,Sampson, J.M.,van den Akker, F.
Novel Insights into the Mode of Inhibition of Class A SHV-1 {beta}-Lactamases Revealed by Boronic Acid Transition State Inhibitors.
Antimicrob.Agents Chemother., 55:174-183, 2011
PubMed: 21041505
DOI: 110.1128/AAC.00930-10
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-09