Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 112 results
7N8Q
DownloadVisualize
BU of 7n8q by Molmil
Rhesusized RV305 DH677.3 Fab bound to Clade A/E 93TH057 HIV-1 gp120 core.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, M48U1 CD4 MIMETIC PEPTIDE, Rhesusized DH677.3 FAB HEAVY CHAIN, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2021-06-15
Release date:2022-04-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s.
Front Immunol, 12, 2021
5KJR
DownloadVisualize
BU of 5kjr by Molmil
Crystal structure of the ADCC-potent antibody N60-i3 Fab in complex with HIV-1 Clade A/E gp120 W69A/S115W mutant and M48U1.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, M48U1 CD4 MIMETIC PEPTIDE, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2016-06-20
Release date:2016-07-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.
J.Virol., 90, 2016
8TTW
DownloadVisualize
BU of 8ttw by Molmil
Cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with temsavir, 8ANC195, and 10-1074
Descriptor: 1-[4-(benzenecarbonyl)piperazin-1-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Tolbert, W.D, Pozharski, E, Pazgier, M.
Deposit date:2023-08-15
Release date:2023-11-08
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Nat Commun, 14, 2023
8SM2
DownloadVisualize
BU of 8sm2 by Molmil
Crystal Structure of the macaque FcalphaRI bound to macaque IgA Fc.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Ig-like domain-containing protein, Immunoglobulin subtype domain-containing protein, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2023-04-25
Release date:2024-05-08
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal Structure of the macaque FcalphaRI bound to macaque IgA Fc.
To Be Published
6UTB
DownloadVisualize
BU of 6utb by Molmil
CRYSTAL STRUCTURE OF UNLIGANDED HIV-1 LM/HT CLADE A/E CRF01 GP120 CORE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 LM/HT Clade A/E CRF01 gp120 core
Authors:Tolbert, W.D, Sherburn, R, Pazgier, M.
Deposit date:2019-10-29
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.
Mbio, 11, 2020
6USW
DownloadVisualize
BU of 6usw by Molmil
CRYSTAL STRUCTURE OF HIV-1 LM/HS CLADE A/E CRF01 GP120 CORE IN COMPLEX WITH (S)-MCG-IV-210
Descriptor: (3S)-N~1~-(2-aminoethyl)-N~3~-(4-chloro-3-fluorophenyl)piperidine-1,3-dicarboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Tolbert, W.D, Sherburn, R, Pazgier, M.
Deposit date:2019-10-28
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.
Mbio, 11, 2020
6UT1
DownloadVisualize
BU of 6ut1 by Molmil
CRYSTAL STRUCTURE OF HIV-1 LM/HS CLADE A/E CRF01 GP120 CORE IN COMPLEX WITH BNM-III-170
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 LM/HS clade A/E CRF01 gp120 core, ...
Authors:Tolbert, W.D, Sherburn, R, Pazgier, M.
Deposit date:2019-10-29
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.
Mbio, 11, 2020
6UTD
DownloadVisualize
BU of 6utd by Molmil
CRYSTAL STRUCTURE OF UNLIGANDED HIV-1 LM/HS CLADE A/E CRF01 GP120 CORE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 LM/HS clade A/E CRF01 gp120 core
Authors:Tolbert, W.D, Sherburn, R, Pazgier, M.
Deposit date:2019-10-29
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site.
Mbio, 11, 2020
1MSV
DownloadVisualize
BU of 1msv by Molmil
The S68A S-adenosylmethionine decarboxylase proenzyme processing mutant.
Descriptor: 1,4-DIAMINOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-adenosylmethionine decarboxylase proenzyme
Authors:Tolbert, W.D, Zhang, Y, Bennett, E.M, Cottet, S.E, Ekstrom, J.L, Pegg, A.E, Ealick, S.E.
Deposit date:2002-09-19
Release date:2003-03-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanism of Human S-Adenosylmethionine Decarboxylase Proenzyme Processing as Revealed by the Structure of the S68A Mutant.
Biochemistry, 42, 2003
6W4M
DownloadVisualize
BU of 6w4m by Molmil
CRYSTAL STRUCTURE OF THE ADCC-POTENT, WEAKLY NEUTRALIZING HIV ENV CO-RECEPTOR BINDING SITE ANTIBODY N12-I2 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND M48U1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTI-HIV ANTIBODY N12-I2 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY N12-I2 FAB LIGHT CHAIN, ...
Authors:Tolbert, W.D, Gohain, N, Pazgier, M.
Deposit date:2020-03-11
Release date:2020-08-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site.
Bmc Biol., 18, 2020
6VSL
DownloadVisualize
BU of 6vsl by Molmil
Crystal structure of a human fucosylated IgG1 Fc expressed in tobacco plants (Nicotiana benthamiana)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2020-02-11
Release date:2021-02-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Enhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells.
J.Virol., 95, 2021
6VSZ
DownloadVisualize
BU of 6vsz by Molmil
Crystal structure of a human afucosylated IgG1 Fc expressed in tobacco plants (Nicotiana benthamiana)
Descriptor: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2020-02-12
Release date:2021-02-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Enhanced Ability of Plant-Derived PGT121 Glycovariants To Eliminate HIV-1-Infected Cells.
J.Virol., 95, 2021
2QJ2
DownloadVisualize
BU of 2qj2 by Molmil
A Mechanistic Basis for Converting a Receptor Tyrosine Kinase Agonist to an Antagonist
Descriptor: Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D, Daugherty, J, Gao, C.-F, Xe, Q, Miranti, C, Gherardi, E, Vande Woude, G, Xu, H.E.
Deposit date:2007-07-06
Release date:2007-09-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QJ4
DownloadVisualize
BU of 2qj4 by Molmil
A Mechanistic Basis for Converting a Receptor Tyrosine Kinase Agonist to an Antagonist
Descriptor: Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D, Daugherty, J, Gao, C.-F, Xe, Q, Miranti, C, Gherardi, E, Vande Woude, G, Xu, H.E.
Deposit date:2007-07-06
Release date:2007-09-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Proc.Natl.Acad.Sci.Usa, 104, 2007
3HMS
DownloadVisualize
BU of 3hms by Molmil
Crystal Crystal structure of the N-terminal fragment (28-126) of the human hepatocyte growth factor/scatter factor, orthorhombic crystal form
Descriptor: Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HMT
DownloadVisualize
BU of 3hmt by Molmil
Crystal structure of the N-terminal fragment (28-126) of the human hepatocyte growth factor/scatter factor, trigonal crystal form
Descriptor: Hepatocyte growth factor
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HMR
DownloadVisualize
BU of 3hmr by Molmil
Crystal structure of the N-terminal fragment (31-127) of the mouse hepatocyte growth factor/scatter factor
Descriptor: Hepatocyte growth factor, SULFATE ION
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HN4
DownloadVisualize
BU of 3hn4 by Molmil
Crystal structure of the NK2 fragment (28-289) of human hepatocyte growth factor/scatter factor
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hepatocyte growth factor, ...
Authors:Tolbert, W.D.
Deposit date:2009-05-29
Release date:2010-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for agonism and antagonism of hepatocyte growth factor.
Proc.Natl.Acad.Sci.USA, 107, 2010
6OZ4
DownloadVisualize
BU of 6oz4 by Molmil
Crystal structure of broadly neutralizing antibody N49P6 Fab in complex with HIV-1 BG505 SOSIP.664 Env trimer ectodomain.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2019-05-15
Release date:2020-08-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (4.05 Å)
Cite:Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer.
Mbio, 2021
6OZ2
DownloadVisualize
BU of 6oz2 by Molmil
Crystal structure of the broadly neutralizing antibody N49P6 Fab in complex with HIV-1 Clade A/E strain 93TH057 gp120 core.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N49P6 antibody Fab heavy chain, N49P6 antibody Fab light chain, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2019-05-15
Release date:2020-08-19
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Near-Pan-neutralizing, Plasma Deconvoluted Antibody N49P6 Mimics Host Receptor CD4 in Its Quaternary Interactions with the HIV-1 Envelope Trimer.
Mbio, 2021
7KCZ
DownloadVisualize
BU of 7kcz by Molmil
CRYSTAL STRUCTURE OF RHESUS MACAQUE (MACACA MULATTA) IGG1 FC FRAGMENT- FC-GAMMA RECEPTOR III COMPLEX V158 MUTANT
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2020-10-07
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques.
Front Immunol, 13, 2022
7KJN
DownloadVisualize
BU of 7kjn by Molmil
CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA)
Descriptor: D-PMI-omega, Protein Mdm4
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2020-10-26
Release date:2021-11-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA)
To Be Published
7KJM
DownloadVisualize
BU of 7kjm by Molmil
CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA)
Descriptor: CHLORIDE ION, D-PMI-omega, DI(HYDROXYETHYL)ETHER, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2020-10-26
Release date:2021-11-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA)
To Be Published
7N0X
DownloadVisualize
BU of 7n0x by Molmil
Rhesusized RV144 DH827 Fab bound to HIV-1 Env V2 peptide
Descriptor: DI(HYDROXYETHYL)ETHER, Glycoprotein 120, Rhesusized RV144 DH827 heavy chain Fab fragment, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2021-05-26
Release date:2022-04-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s.
Front Immunol, 12, 2021
5VK0
DownloadVisualize
BU of 5vk0 by Molmil
Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
Authors:Tolbert, W.D, Gohain, N, Pazgier, M.
Deposit date:2017-04-20
Release date:2018-04-25
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.
Chem Sci, 10, 2019

220472

PDB entries from 2024-05-29

PDB statisticsPDBj update infoContact PDBjnumon