5KJR

Crystal structure of the ADCC-potent antibody N60-i3 Fab in complex with HIV-1 Clade A/E gp120 W69A/S115W mutant and M48U1.

Summary for 5KJR

• Entry DOI: 10.2210/pdb5kjr/pdb
• Related: 4RFO
• Related PRD ID: PRD_001094
• Descriptor: clade A/E 93TH057 HIV-1 gp120 core, M48U1 CD4 MIMETIC PEPTIDE, N60-I3 FAB HEAVY CHAIN, ... (7 entities in total)
• Functional Keywords: hiv-1 gp120, clade a/e 93th057, viral protein, viral protein-immune system-inhibitor complex, viral protein/immune system/inhibitor
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 4
• Total formula weight: 92286.50

Authors

Tolbert, W.D.,Pazgier, M. (deposition date: 2016-06-20, release date: 2016-07-20, Last modification date: 2023-11-15)

• Primary citation: Ding, S.,Tolbert, W.D.,Prevost, J.,Pacheco, B.,Coutu, M.,Debbeche, O.,Xiang, S.H.,Pazgier, M.,Finzi, A.; A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.; J.Virol., 90:8395-8409, 2016; PubMed: 27384653; DOI: 10.1128/JVI.01068-16

Experimental method

X-RAY DIFFRACTION (2.98 Å)