5KJR
Crystal structure of the ADCC-potent antibody N60-i3 Fab in complex with HIV-1 Clade A/E gp120 W69A/S115W mutant and M48U1.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | clade A/E 93TH057 HIV-1 gp120 core | polymer | 353 | 39144.4 | 1 | UniProt (A0A0M3KKW9) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 2 | B (N) | M48U1 CD4 MIMETIC PEPTIDE | polymer | 28 | 3056.8 | 1 | BIRD (PRD_001094) | synthetic construct | |
| 3 | C (H) | N60-I3 FAB HEAVY CHAIN | polymer | 229 | 24412.4 | 1 | Homo sapiens | ||
| 4 | D (L) | N60-I3 FAB LIGHT CHAIN | polymer | 221 | 23342.7 | 1 | Homo sapiens | ||
| 5 | E, F, G, H, I... (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 10 | Chemie (NAG) | |||
| 6 | O (L) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 7 | P, Q, R (G, H, L) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
G: 44 - 492 (UniProt: A0A0M3KKW9)
| PDB | External Database | Details |
|---|---|---|
| Ala 69 | Trp 26 | engineered mutation |
| Trp 115 | Ser 72 | engineered mutation |
| Ser 375 | His 242 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 89956.3 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2330.3 | |
| All* | Total formula weight | 92286.5 |
