1ALU
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![BU of 1alu by Molmil](/molmil-images/mine/1alu) | HUMAN INTERLEUKIN-6 | Descriptor: | INTERLEUKIN-6, L(+)-TARTARIC ACID, SULFATE ION | Authors: | Somers, W.S, Stahl, M, Seehra, J.S. | Deposit date: | 1997-06-03 | Release date: | 1998-06-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | 1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling. EMBO J., 16, 1997
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1CMA
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![BU of 1cma by Molmil](/molmil-images/mine/1cma) | MET REPRESSOR/DNA COMPLEX + S-ADENOSYL-METHIONINE | Descriptor: | DNA (5'-D(*AP*GP*AP*CP*GP*TP*CP*TP*A)-3'), DNA (5'-D(*TP*TP*AP*GP*AP*CP*GP*TP*CP*T)-3'), PROTEIN (MET REPRESSOR), ... | Authors: | Somers, W.S, Phillips, S.E.V. | Deposit date: | 1992-08-24 | Release date: | 1993-10-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the met repressor-operator complex at 2.8 A resolution reveals DNA recognition by beta-strands. Nature, 359, 1992
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1BSV
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![BU of 1bsv by Molmil](/molmil-images/mine/1bsv) | GDP-FUCOSE SYNTHETASE FROM ESCHERICHIA COLI COMPLEX WITH NADPH | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTEIN (GDP-FUCOSE SYNTHETASE) | Authors: | Somers, W.S, Stahl, M.L, Sullivan, F.X. | Deposit date: | 1998-08-31 | Release date: | 1999-08-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site. Structure, 6, 1998
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1BP3
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![BU of 1bp3 by Molmil](/molmil-images/mine/1bp3) | THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX | Descriptor: | PROTEIN (GROWTH HORMONE), PROTEIN (PROLACTIN RECEPTOR), ZINC ION | Authors: | Somers, W, Ultsch, M, De Vos, A.M, Kossiakoff, A.A. | Deposit date: | 1998-08-12 | Release date: | 1998-08-19 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The X-ray structure of a growth hormone-prolactin receptor complex. Nature, 372, 1994
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1CMC
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1G1R
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![BU of 1g1r by Molmil](/molmil-images/mine/1g1r) | Crystal structure of P-selectin lectin/EGF domains complexed with SLeX | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, CALCIUM ION, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside, ... | Authors: | Somers, W.S, Camphausen, R.T. | Deposit date: | 2000-10-13 | Release date: | 2001-10-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell(Cambridge,Mass.), 103, 2000
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1G1S
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![BU of 1g1s by Molmil](/molmil-images/mine/1g1s) | P-SELECTIN LECTIN/EGF DOMAINS COMPLEXED WITH PSGL-1 PEPTIDE | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-[beta-D-galactopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-galactopyranose, P-SELECTIN, ... | Authors: | Somers, W.S, Camphausen, R.T. | Deposit date: | 2000-10-13 | Release date: | 2001-10-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell(Cambridge,Mass.), 103, 2000
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1G1T
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![BU of 1g1t by Molmil](/molmil-images/mine/1g1t) | CRYSTAL STRUCTURE OF E-SELECTIN LECTIN/EGF DOMAINS COMPLEXED WITH SLEX | Descriptor: | CALCIUM ION, E-SELECTIN, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside | Authors: | Somers, W.S, Camphausen, R.T. | Deposit date: | 2000-10-13 | Release date: | 2001-10-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell(Cambridge,Mass.), 103, 2000
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1G1Q
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![BU of 1g1q by Molmil](/molmil-images/mine/1g1q) | Crystal structure of P-selectin lectin/EGF domains | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, CALCIUM ION, P-SELECTIN | Authors: | Somers, W.S, Camphausen, R.T. | Deposit date: | 2000-10-13 | Release date: | 2001-10-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell(Cambridge,Mass.), 103, 2000
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1GFS
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![BU of 1gfs by Molmil](/molmil-images/mine/1gfs) | GDP-FUCOSE SYNTHETASE FROM E. COLI | Descriptor: | GDP-FUCOSE SYNTHETASE | Authors: | Somers, W.S, Stahl, M.L, Sullivan, F.X. | Deposit date: | 1998-08-17 | Release date: | 1999-08-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site. Structure, 6, 1998
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1FXS
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![BU of 1fxs by Molmil](/molmil-images/mine/1fxs) | GDP-FUCOSE SYNTHETASE FROM ESCHERICHIA COLI COMPLEX WITH NADP | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTEIN (GDP-FUCOSE SYNTHETASE) | Authors: | Somers, W.S, Stahl, M.L, Sullivan, F.X. | Deposit date: | 1998-09-01 | Release date: | 1999-08-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site. Structure, 6, 1998
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1X78
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![BU of 1x78 by Molmil](/molmil-images/mine/1x78) | CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-244 | Descriptor: | Estrogen receptor beta, STEROID RECEPTOR COACTIVATOR-1, [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE | Authors: | Manas, E.S, Unwalla, R.J, Xu, Z.B, Malamas, M.S, Miller, C.P, Harris, H.A, Hsiao, C, Akopian, T, Hum, W.T, Malakian, K, Wolfrom, S, Bapat, A, Bhat, R.A, Stahl, M.L, Somers, W.S, Alvarez, J.C. | Deposit date: | 2004-08-13 | Release date: | 2005-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-Based Design of Estrogen Receptor-Beta Selective Ligands J.Am.Chem.Soc., 126, 2004
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2RJQ
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![BU of 2rjq by Molmil](/molmil-images/mine/2rjq) | Crystal structure of ADAMTS5 with inhibitor bound | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, ADAMTS-5, ... | Authors: | Mosyak, L, Stahl, M, Somers, W. | Deposit date: | 2007-10-15 | Release date: | 2007-12-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci., 17, 2008
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1X7J
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![BU of 1x7j by Molmil](/molmil-images/mine/1x7j) | CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH GENISTEIN | Descriptor: | Estrogen receptor beta, GENISTEIN, STEROID RECEPTOR COACTIVATOR-1 | Authors: | Manas, E.S, Xu, Z.B, Unwalla, R.J, Somers, W.S. | Deposit date: | 2004-08-14 | Release date: | 2005-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Understanding the Selectivity of Genistein for Human Estrogen Receptor-Beta Using X-Ray Crystallography and Computational Methods Structure, 12, 2004
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1X7R
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![BU of 1x7r by Molmil](/molmil-images/mine/1x7r) | CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH GENISTEIN | Descriptor: | Estrogen receptor 1 (alpha), GENISTEIN, steroid receptor coactivator-3 | Authors: | Manas, E.S, Xu, Z.B, Unwalla, R.J, Somers, W.S. | Deposit date: | 2004-08-16 | Release date: | 2005-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Understanding the Selectivity of Genistein for Human Estrogen Receptor-Beta Using X-Ray Crystallography and Computational Methods Structure, 12, 2004
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2ID5
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![BU of 2id5 by Molmil](/molmil-images/mine/2id5) | Crystal Structure of the Lingo-1 Ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine rich repeat neuronal 6A, ... | Authors: | Mosyak, L, Wood, A, Dwyer, B, Johnson, M, Stahl, M.L, Somers, W.S. | Deposit date: | 2006-09-14 | Release date: | 2006-09-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.698 Å) | Cite: | The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. J.Biol.Chem., 281, 2006
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4J12
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![BU of 4j12 by Molmil](/molmil-images/mine/4j12) | monomeric Fc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, human Fc fragment | Authors: | Ishino, T, Wang, M, Mosyak, L, Tam, A, Duan, W, Svenson, K, Joyce, A, O'Hara, D, Lin, L, Somers, W, Kriz, R. | Deposit date: | 2013-01-31 | Release date: | 2013-05-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics. J.Biol.Chem., 288, 2013
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1X7B
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![BU of 1x7b by Molmil](/molmil-images/mine/1x7b) | CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH ERB-041 | Descriptor: | 2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL, Estrogen receptor beta, STEROID RECEPTOR COACTIVATOR-1 | Authors: | Manas, E.S, Unwalla, R.J, Xu, Z.B, Malamas, M.S, Miller, C.P, Harris, H.A, Hsiao, C, Akopian, T, Hum, W.T, Malakian, K, Wolfrom, S, Bapat, A, Bhat, R.A, Stahl, M.L, Somers, W.S, Alvarez, J.C. | Deposit date: | 2004-08-13 | Release date: | 2005-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-Based Design of Estrogen Receptor-Beta Selective Ligands J.Am.Chem.Soc., 126, 2004
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1X76
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![BU of 1x76 by Molmil](/molmil-images/mine/1x76) | CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR BETA COMPLEXED WITH WAY-697 | Descriptor: | 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE, Estrogen receptor beta, STEROID RECEPTOR COACTIVATOR-1 | Authors: | Manas, E.S, Unwalla, R.J, Xu, Z.B, Malamas, M.S, Miller, C.P, Harris, H.A, Hsiao, C, Akopian, T, Hum, W.T, Malakian, K, Wolfrom, S, Bapat, A, Bhat, R.A, Stahl, M.L, Somers, W.S, Alvarez, J.C. | Deposit date: | 2004-08-13 | Release date: | 2005-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Based Design of Estrogen Receptor-Beta Selective Ligands J.Am.Chem.Soc., 126, 2004
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1X7E
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![BU of 1x7e by Molmil](/molmil-images/mine/1x7e) | CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH WAY-244 | Descriptor: | Estrogen receptor 1 (alpha), [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE, steroid receptor coactivator-3 | Authors: | Manas, E.S, Unwalla, R.J, Xu, Z.B, Malamas, M.S, Miller, C.P, Harris, H.A, Hsiao, C, Akopian, T, Hum, W.T, Malakian, K, Wolfrom, S, Bapat, A, Bhat, R.A, Stahl, M.L, Somers, W.S, Alvarez, J.C. | Deposit date: | 2004-08-13 | Release date: | 2005-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-Based Design of Estrogen Receptor-Beta Selective Ligands J.Am.Chem.Soc., 126, 2004
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2RJP
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![BU of 2rjp by Molmil](/molmil-images/mine/2rjp) | Crystal structure of ADAMTS4 with inhibitor bound | Descriptor: | ADAMTS-4, CALCIUM ION, N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}sulfonyl)-D-valine, ... | Authors: | Mosyak, L, Stahl, M, Somers, W. | Deposit date: | 2007-10-15 | Release date: | 2007-12-11 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci., 17, 2008
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3B2Z
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![BU of 3b2z by Molmil](/molmil-images/mine/3b2z) | Crystal Structure of ADAMTS4 (apo form) | Descriptor: | ADAMTS-4, CALCIUM ION, ZINC ION | Authors: | Mosyak, L, Stahl, M, Somers, W. | Deposit date: | 2007-10-19 | Release date: | 2007-12-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci., 17, 2008
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1S1G
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![BU of 1s1g by Molmil](/molmil-images/mine/1s1g) | Crystal Structure of Kv4.3 T1 Domain | Descriptor: | Potassium voltage-gated channel subfamily D member 3, ZINC ION | Authors: | Scannevin, R.H, Wang, K.W, Jow, F, Megules, J, Kopsco, D.C, Edris, W, Carroll, K.C, Lu, Q, Xu, W.X, Xu, Z.B, Katz, A.H, Olland, S, Lin, L, Taylor, M, Stahl, M, Malakian, K, Somers, W, Mosyak, L, Bowlby, M.R, Chanda, P, Rhodes, K.J. | Deposit date: | 2004-01-06 | Release date: | 2004-03-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. Neuron, 41, 2004
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1S1E
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![BU of 1s1e by Molmil](/molmil-images/mine/1s1e) | Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1) | Descriptor: | CALCIUM ION, Kv channel interacting protein 1 | Authors: | Scannevin, R.H, Wang, K.-W, Jow, F, Megules, J, Kopsco, D.C, Edris, W, Carroll, K.C, Lu, Q, Xu, W.-X, Xu, Z.-B, Katz, A.H, Olland, S, Lin, L, Taylor, M, Stahl, M, Malakian, K, Somers, W, Mosyak, L, Bowlby, M.R, Chanda, P, Rhodes, K.J. | Deposit date: | 2004-01-06 | Release date: | 2005-01-11 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. Neuron, 41, 2004
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1NY3
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![BU of 1ny3 by Molmil](/molmil-images/mine/1ny3) | Crystal structure of ADP bound to MAP KAP kinase 2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAP kinase-activated protein kinase 2 | Authors: | Underwood, K.W, Parris, K.D, Federico, E, Mosyak, L, Shane, T, Taylor, M, Svenson, K, Liu, Y, Hsiao, C.L, Wolfrom, S, Maguire, M, Malakian, K, Telliez, J.B, Lin, L.L, Kriz, R.W, Seehra, J, Somers, W.S, Stahl, M.L. | Deposit date: | 2003-02-11 | Release date: | 2003-10-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme Structure, 11, 2003
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