1GFS

GDP-FUCOSE SYNTHETASE FROM E. COLI

Summary for 1GFS

Entry DOI	10.2210/pdb1gfs/pdb
Descriptor	GDP-FUCOSE SYNTHETASE (2 entities in total)
Functional Keywords	epimerase-reductase, nadp, gdp-fucose, lipopolysaccharide biosynthesis, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	36187.10
Authors	Somers, W.S.,Stahl, M.L.,Sullivan, F.X. (deposition date: 1998-08-17, release date: 1999-08-17, Last modification date: 2024-02-07)
Primary citation	Somers, W.S.,Stahl, M.L.,Sullivan, F.X. GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site. Structure, 6:1601-1612, 1998 Cited by PubMed Abstract: . In all species examined, GDP-fucose is synthesized from GDP-mannose in a three-step reaction catalyzed by two enzymes, GDP-mannose 4,6 dehydratase and a dual function 3, 5-epimerase-4-reductase named GDP-fucose synthetase. In this latter aspect fucose biosynthesis differs from that of other deoxy and dideoxy sugars, in which the epimerase and reductase activities are present as separate enzymes. Defects in GDP-fucose biosynthesis have been shown to affect nodulation in bacteria, stem development in plants, and are associated with the immune defect leukocyte adhesion deficiency type II in humans. PubMed: 9862812 DOI: 10.1016/S0969-2126(98)00157-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation