4J12

monomeric Fc

Summary for 4J12

Descriptorhuman Fc fragment, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ... (5 entities in total)
Functional Keywordsimmunoglobulin fold, immune system
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight25434.28
Authors
Ishino, T.,Wang, M.,Mosyak, L.,Tam, A.,Duan, W.,Svenson, K.,Joyce, A.,O'Hara, D.,Lin, L.,Somers, W.,Kriz, R. (deposition date: 2013-01-31, release date: 2013-05-01, Last modification date: 2018-06-13)
Primary citation
Ishino, T.,Wang, M.,Mosyak, L.,Tam, A.,Duan, W.,Svenson, K.,Joyce, A.,O'Hara, D.M.,Lin, L.,Somers, W.S.,Kriz, R.
Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics.
J.Biol.Chem., 288:16529-16537, 2013
PubMed: 23615911 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M113.457689
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2493006.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4j12
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Molmil generated image of 4j12
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Molmil generated image of 4j12
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More Biological unit images

Molmil generated image of 4j12
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Molmil generated image of 4j12
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Molmil generated image of 4j12
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4j12.pdb2.gz [79.08 KB])
Coordinate files for Biological unit (4j12.pdb1.gz [40.44 KB])