4J12

monomeric Fc

Summary for 4J12

• Entry DOI: 10.2210/pdb4j12/pdb
• Descriptor: human Fc fragment, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: immunoglobulin fold, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 25326.18

Authors

Ishino, T.,Wang, M.,Mosyak, L.,Tam, A.,Duan, W.,Svenson, K.,Joyce, A.,O'Hara, D.,Lin, L.,Somers, W.,Kriz, R. (deposition date: 2013-01-31, release date: 2013-05-01, Last modification date: 2020-07-29)

• Primary citation: Ishino, T.,Wang, M.,Mosyak, L.,Tam, A.,Duan, W.,Svenson, K.,Joyce, A.,O'Hara, D.M.,Lin, L.,Somers, W.S.,Kriz, R.; Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics.; J.Biol.Chem., 288:16529-16537, 2013; PubMed: 23615911; DOI: 10.1074/jbc.M113.457689

Experimental method

X-RAY DIFFRACTION (1.9 Å)