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2RJP

Crystal structure of ADAMTS4 with inhibitor bound

Summary for 2RJP
Entry DOI10.2210/pdb2rjp/pdb
Related2RJQ 3B2Z
DescriptorADAMTS-4, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsmetalloprotease domain, aggrecanase, cleavage on pair of basic residues, extracellular matrix, glycoprotein, hydrolase, metal-binding, polymorphism, secreted, zinc, zymogen
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix (By similarity): O75173
Total number of polymer chains4
Total formula weight139667.67
Authors
Mosyak, L.,Stahl, M.,Somers, W. (deposition date: 2007-10-15, release date: 2007-12-11, Last modification date: 2021-10-20)
Primary citationMosyak, L.,Georgiadis, K.,Shane, T.,Svenson, K.,Hebert, T.,McDonagh, T.,Mackie, S.,Olland, S.,Lin, L.,Zhong, X.,Kriz, R.,Reifenberg, E.L.,Collins-Racie, L.A.,Corcoran, C.,Freeman, B.,Zollner, R.,Marvell, T.,Vera, M.,Sum, P.E.,Lavallie, E.R.,Stahl, M.,Somers, W.
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17:16-21, 2008
Cited by
PubMed: 18042673
DOI: 10.1110/ps.073287008
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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