Crystal structure of ADAMTS4 with inhibitor bound

Summary for 2RJP

Related2RJQ 3B2Z
DescriptorADAMTS-4, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsmetalloprotease domain, aggrecanase, cleavage on pair of basic residues, extracellular matrix, glycoprotein, hydrolase, metal-binding, polymorphism, secreted, zinc, zymogen
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix (By similarity) O75173
Total number of polymer chains4
Total molecular weight139667.67
Mosyak, L.,Stahl, M.,Somers, W. (deposition date: 2007-10-15, release date: 2007-12-11, Last modification date: 2011-07-13)
Primary citation
Mosyak, L.,Georgiadis, K.,Shane, T.,Svenson, K.,Hebert, T.,McDonagh, T.,Mackie, S.,Olland, S.,Lin, L.,Zhong, X.,Kriz, R.,Reifenberg, E.L.,Collins-Racie, L.A.,Corcoran, C.,Freeman, B.,Zollner, R.,Marvell, T.,Vera, M.,Sum, P.E.,Lavallie, E.R.,Stahl, M.,Somers, W.
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17:16-21, 2008
PubMed: 18042673 (PDB entries with the same primary citation)
DOI: 10.1110/ps.073287008
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers40.9%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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