Crystal structure of ADAMTS5 with inhibitor bound

Summary for 2RJQ

Related2RJP 3B2Z
DescriptorADAMTS-5, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ... (7 entities in total)
Functional Keywordsmetalloprotease domain, aggrecanase, cleavage on pair of basic residues, extracellular matrix, glycoprotein, hydrolase, metal-binding, secreted, zymogen
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix  Q9UNA0
Total number of polymer chains1
Total molecular weight42853.17
Mosyak, L.,Stahl, M.,Somers, W. (deposition date: 2007-10-15, release date: 2007-12-11, Last modification date: 2017-10-25)
Primary citation
Mosyak, L.,Georgiadis, K.,Shane, T.,Svenson, K.,Hebert, T.,McDonagh, T.,Mackie, S.,Olland, S.,Lin, L.,Zhong, X.,Kriz, R.,Reifenberg, E.L.,Collins-Racie, L.A.,Corcoran, C.,Freeman, B.,Zollner, R.,Marvell, T.,Vera, M.,Sum, P.E.,Lavallie, E.R.,Stahl, M.,Somers, W.
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17:16-21, 2008
PubMed: 18042673 (PDB entries with the same primary citation)
DOI: 10.1110/ps.073287008
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers301.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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