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2RJQ

Crystal structure of ADAMTS5 with inhibitor bound

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AADAMTS-5polymer37841651.21UniProt (Q9UNA0)
Pfam (PF01421)
Pfam (PF17771)
Pfam (PF00090)
In PDB
Homo sapiens (human)A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 5, ADAM-TS5, Aggrecanase-2, ADMP-2, ADAM-TS 11
2B2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G42666HT)
3AZINC IONnon-polymer65.42Chemie (ZN)
4ACHLORIDE IONnon-polymer35.52Chemie (CL)
5ACALCIUM IONnon-polymer40.12Chemie (CA)
6A4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDEnon-polymer477.61Chemie (BAT)
7waterwater18.081Chemie (HOH)
Sequence modifications
A: 262 - 628 (UniProt: Q9UNA0)
PDBExternal DatabaseDetails
Gly 629-expression tag
Ser 630-expression tag
Ala 631-expression tag
Trp 632-expression tag
Ser 633-expression tag
His 634-expression tag
Pro 635-expression tag
Gln 636-expression tag
Phe 637-expression tag
Glu 638-expression tag
Lys 639-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight41651.2
BranchedNumber of molecules1
Total formula weight424.4
Non-Polymers*Number of molecules7
Total formula weight759.5
All*Total formula weight42835.2
*Water molecules are not included.

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PDB entries from 2024-09-18

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