2RJQ
Crystal structure of ADAMTS5 with inhibitor bound
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHEIGHLL |
| Chain | Residue | Details |
| A | THR407-LEU416 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673 |
| Chain | Residue | Details |
| A | GLU411 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18042673 |
| Chain | Residue | Details |
| A | HIS410 | |
| A | HIS414 | |
| A | HIS420 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18042673 |
| Chain | Residue | Details |
| A | ASN498 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: C-linked (Man) tryptophan => ECO:0000269|PubMed:19671700 |
| Chain | Residue | Details |
| A | TRP570 | |
| A | TRP573 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (Fuc...) serine => ECO:0000269|PubMed:19671700 |
| Chain | Residue | Details |
| A | SER582 |
