2RJP
Crystal structure of ADAMTS4 with inhibitor bound
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | ADAMTS-4 | polymer | 316 | 34221.7 | 4 | UniProt (O75173) Pfam (PF01421) Pfam (PF17771) In PDB | Homo sapiens (human) | A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, Aggrecanase-1, ADMP-1 |
2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | A, B, C, D | CALCIUM ION | non-polymer | 40.1 | 12 | Chemie (CA) | |||
4 | A, B, C, D | N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}sulfonyl)-D-valine | non-polymer | 509.6 | 4 | Chemie (886) | |||
5 | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 213 - 520 (UniProt: O75173)
PDB | External Database | Details |
---|---|---|
Gln 362 | Glu 362 | engineered mutation |
Asp 521 | - | expression tag |
Tyr 522 | - | expression tag |
Lys 523 | - | expression tag |
Asp 524 | - | expression tag |
Asp 525 | - | expression tag |
Asp 526 | - | expression tag |
Asp 527 | - | expression tag |
Lys 528 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 136886.6 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 2781.0 | |
All* | Total formula weight | 139667.7 |