2RJP
Crystal structure of ADAMTS4 with inhibitor bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ADAMTS-4 | polymer | 316 | 34221.7 | 4 | UniProt (O75173) Pfam (PF01421) Pfam (PF17771) | Homo sapiens (human) | A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, Aggrecanase-1, ADMP-1 |
| 2 | E, J, O, T (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, G, H, K, L... (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 12 | Chemie (CA) | |||
| 4 | I, N, S, X (A, B, C, D) | N-({4'-[(4-isobutyrylphenoxy)methyl]biphenyl-4-yl}sulfonyl)-D-valine | non-polymer | 509.6 | 4 | Chemie (886) | |||
| 5 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 213 - 520 (UniProt: O75173)
| PDB | External Database | Details |
|---|---|---|
| Gln 362 | Glu 362 | engineered mutation |
| Asp 521 | - | expression tag |
| Tyr 522 | - | expression tag |
| Lys 523 | - | expression tag |
| Asp 524 | - | expression tag |
| Asp 525 | - | expression tag |
| Asp 526 | - | expression tag |
| Asp 527 | - | expression tag |
| Lys 528 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 136886.6 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2781.0 | |
| All* | Total formula weight | 139667.7 |
