1X7E

CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH WAY-244

Summary for 1X7E

• Entry DOI: 10.2210/pdb1x7e/pdb
• Related: 1U3Q 1U3R 1U3S 1U9E 1X76 1X78 1X7B 1X7D 1X7J 1X7R
• Descriptor: Estrogen receptor 1 (alpha), steroid receptor coactivator-3, [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE, ... (4 entities in total)
• Functional Keywords: estrogen receptor, estrogen receptor beta, er-beta, er, estrogen receptor alpha, er-alpha, estrogen, nuclear recept transcription factor, agonist, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Nucleus. Isoform 3: Nucleus: P03372
• Total number of polymer chains: 4
• Total formula weight: 59818.49

Authors

Manas, E.S.,Unwalla, R.J.,Xu, Z.B.,Malamas, M.S.,Miller, C.P.,Harris, H.A.,Hsiao, C.,Akopian, T.,Hum, W.T.,Malakian, K.,Wolfrom, S.,Bapat, A.,Bhat, R.A.,Stahl, M.L.,Somers, W.S.,Alvarez, J.C. (deposition date: 2004-08-13, release date: 2005-03-01, Last modification date: 2024-04-03)

• Primary citation: Manas, E.S.,Unwalla, R.J.,Xu, Z.B.,Malamas, M.S.,Miller, C.P.,Harris, H.A.,Hsiao, C.,Akopian, T.,Hum, W.T.,Malakian, K.,Wolfrom, S.,Bapat, A.,Bhat, R.A.,Stahl, M.L.,Somers, W.S.,Alvarez, J.C.; Structure-Based Design of Estrogen Receptor-Beta Selective Ligands; J.Am.Chem.Soc., 126:15106-15119, 2004; PubMed: 15548008; DOI: 10.1021/ja047633o

Experimental method

X-RAY DIFFRACTION (2.8 Å)