5LX5
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![BU of 5lx5 by Molmil](/molmil-images/mine/5lx5) | CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782-RP. | Descriptor: | DIPHOSPHATE, Nicotinamide phosphoribosyltransferase, [(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-5-[[[4-[6-(ethylamino)-5-(2-piperidin-1-ylethylcarbamoyl)pyridin-2-yl]-2-fluoranyl-phenyl]carbamoylamino]methyl]pyridin-1-ium-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Bertrand, T, Marquette, J.P. | Deposit date: | 2016-09-20 | Release date: | 2017-10-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782-RP To Be Published
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5LX3
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![BU of 5lx3 by Molmil](/molmil-images/mine/5lx3) | CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782. | Descriptor: | 6-[4-[(6-azanylpyridin-3-yl)methylcarbamoylamino]-3-fluoranyl-phenyl]-2-(ethylamino)-~{N}-(2-piperidin-1-ylethyl)pyridine-3-carboxamide, Nicotinamide phosphoribosyltransferase | Authors: | Bertrand, T, Marquette, J.P. | Deposit date: | 2016-09-20 | Release date: | 2017-10-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | CRYSTAL STRUCTURE OF VISFATIN IN COMPLEX WITH SAR154782. To Be Published
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2PLO
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![BU of 2plo by Molmil](/molmil-images/mine/2plo) | |
8F5X
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![BU of 8f5x by Molmil](/molmil-images/mine/8f5x) | Crystal structure of human eosinophil-derived neurotoxin (EDN, ribonuclease 2) in complex with 5'-adenosine monophosphate (AMP) | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, Non-secretory ribonuclease, ... | Authors: | Tran, T.T.Q, Pham, N.T.H, Calmettes, C, Doucet, N. | Deposit date: | 2022-11-15 | Release date: | 2023-11-29 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases. J.Biol.Chem., 300, 2024
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3LD4
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![BU of 3ld4 by Molmil](/molmil-images/mine/3ld4) | Urate oxidase complexed with 8-nitro xanthine | Descriptor: | 1,2-ETHANEDIOL, 8-nitro-3,7-dihydro-1H-purine-2,6-dione, SODIUM ION, ... | Authors: | Prange, T, Colloc'h, N, Gabison, L. | Deposit date: | 2010-01-12 | Release date: | 2010-06-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand. Acta Crystallogr.,Sect.D, 66, 2010
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3KXU
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![BU of 3kxu by Molmil](/molmil-images/mine/3kxu) | Crystal structure of human ferritin FTL498InsTC pathogenic mutant | Descriptor: | CADMIUM ION, Ferritin, SULFATE ION | Authors: | Granier, T, Gallois, B, Langlois d'Estaintot, B, Arosio, P. | Deposit date: | 2009-12-04 | Release date: | 2010-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J.Biol.Chem., 285, 2010
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3LBG
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![BU of 3lbg by Molmil](/molmil-images/mine/3lbg) | Urate oxidase complexed with 8-thio xanthine | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 8-thioxo-3,7,8,9-tetrahydro-1H-purine-2,6-dione, ... | Authors: | Prange, T, Colloc'h, N, Gabison, L. | Deposit date: | 2010-01-08 | Release date: | 2010-06-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Near-atomic resolution structures of urate oxidase complexed with its substrate and analogues: the protonation state of the ligand. Acta Crystallogr.,Sect.D, 66, 2010
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2A32
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![BU of 2a32 by Molmil](/molmil-images/mine/2a32) | Trypsin in complex with benzene boronic acid | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, BORATE ION, CALCIUM ION, ... | Authors: | Transue, T.R, Gabel, S.A, London, R.E. | Deposit date: | 2005-06-23 | Release date: | 2006-07-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | NMR and crystallographic characterization of adventitious borate binding by trypsin. Bioconjug.Chem., 17, 2006
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2A31
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![BU of 2a31 by Molmil](/molmil-images/mine/2a31) | Trypsin in complex with borate | Descriptor: | BORATE ION, CALCIUM ION, GUANIDINE-3-PROPANOL, ... | Authors: | Transue, T.R, Gabel, S.A, London, R.E. | Deposit date: | 2005-06-23 | Release date: | 2006-07-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | NMR and crystallographic characterization of adventitious borate binding by trypsin. Bioconjug.Chem., 17, 2006
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6EBX
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![BU of 6ebx by Molmil](/molmil-images/mine/6ebx) | |
3F9A
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![BU of 3f9a by Molmil](/molmil-images/mine/3f9a) | W354F Yersinia enterocolitica PTPase complexed with tungstate | Descriptor: | TUNGSTATE(VI)ION, Tyrosine-protein phosphatase yopH | Authors: | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | Deposit date: | 2008-11-13 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc., 131, 2009
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3F9B
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![BU of 3f9b by Molmil](/molmil-images/mine/3f9b) | W354F Yersinia enterocolitica PTPase complexed with divanadate | Descriptor: | Divanadate ion, GLYCEROL, Tyrosine-protein phosphatase yopH, ... | Authors: | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | Deposit date: | 2008-11-13 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc., 131, 2009
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5GK5
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![BU of 5gk5 by Molmil](/molmil-images/mine/5gk5) | Apo structure of fructose 1,6-bisphosphate aldolase from Escherichia coli at 1.9 angstrom resolution | Descriptor: | DI(HYDROXYETHYL)ETHER, Fructose-bisphosphate aldolase class 2, GLYCEROL, ... | Authors: | Tran, T.H, Huynh, K.H, Ho, T.H, Kang, L.W. | Deposit date: | 2016-07-03 | Release date: | 2017-07-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Apo structure of fructose 1,6-bisphosphate aldolase from Escherichia coli at 1.9 angstrom resolution To Be Published
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8ST7
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![BU of 8st7 by Molmil](/molmil-images/mine/8st7) | Structure of E3 ligase VsHECT bound to ubiquitin | Descriptor: | E3 ubiquitin-protein ligase SopA-like catalytic domain-containing protein, Ubiquitin, prop-2-en-1-amine | Authors: | Franklin, T.G, Pruneda, J.N. | Deposit date: | 2023-05-09 | Release date: | 2023-07-12 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Bacterial ligases reveal fundamental principles of polyubiquitin specificity. Mol.Cell, 83, 2023
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8ST9
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![BU of 8st9 by Molmil](/molmil-images/mine/8st9) | |
8ST8
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![BU of 8st8 by Molmil](/molmil-images/mine/8st8) | |
8STM
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![BU of 8stm by Molmil](/molmil-images/mine/8stm) | Crystal structure of KRAS-G75A mutant, GDP-bound | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Tran, T.H, Dharmaiah, S, Simanshu, D.K. | Deposit date: | 2023-05-10 | Release date: | 2023-08-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity. Cancer Res., 83, 2023
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6VJJ
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![BU of 6vjj by Molmil](/molmil-images/mine/6vjj) | Crystal Structure of wild-type KRAS4b (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Tran, T.H, Dharmaiah, S, Simanshu, D.K. | Deposit date: | 2020-01-16 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
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6EST
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![BU of 6est by Molmil](/molmil-images/mine/6est) | |
8STN
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![BU of 8stn by Molmil](/molmil-images/mine/8stn) | Crystal structure of KRAS-G12D/G75A mutant, GDP-bound | Descriptor: | CHLORIDE ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Tran, T.H, Dharmaiah, S, Simanshu, D.K. | Deposit date: | 2023-05-10 | Release date: | 2023-08-23 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity. Cancer Res., 83, 2023
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6GDD
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![BU of 6gdd by Molmil](/molmil-images/mine/6gdd) | DIHYDROOROTASE FROM AQUIFEX AEOLICUS UNDER 1200 BAR OF HYDROSTATIC PRESSURE | Descriptor: | Dihydroorotase, SULFATE ION, ZINC ION | Authors: | Prange, T, Girard, E, Herve, G, Evans, D.R. | Deposit date: | 2018-04-23 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Pressure-induced activation of latent dihydroorotase from Aquifex aeolicus as revealed by high pressure protein crystallography. Febs J., 286, 2019
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1R51
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![BU of 1r51 by Molmil](/molmil-images/mine/1r51) | URATE OXIDASE FROM ASPERGILLUS FLAVUS COMPLEXED WITH ITS INHIBITOR 8-AZAXANTHIN | Descriptor: | 8-AZAXANTHINE, CYSTEINE, Uricase | Authors: | Prange, T, Retailleau, P, Colloc'h, N. | Deposit date: | 2003-10-09 | Release date: | 2004-03-02 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode. Acta Crystallogr.,Sect.D, 60, 2004
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3AUL
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![BU of 3aul by Molmil](/molmil-images/mine/3aul) | Crystal structure of wild-type Lys48-linked diubiquitin in an open conformation | Descriptor: | Polyubiquitin-C | Authors: | Hirano, T, Olivier, S, Yagi, M, Takemoto, E, Hiromoto, T, Satoh, T, Mizushima, T, Kato, K. | Deposit date: | 2011-02-09 | Release date: | 2011-09-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Conformational dynamics of wild-type Lys48-linked diubiquitin in solution J.Biol.Chem., 286, 2011
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6GDE
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![BU of 6gde by Molmil](/molmil-images/mine/6gde) | DIHYDROOROTASE FROM AQUIFEX AEOLICUS STANDARD (P,T) | Descriptor: | Dihydroorotase, ZINC ION | Authors: | Prange, T, Girard, E, Herve, G, Evans, D. | Deposit date: | 2018-04-23 | Release date: | 2019-01-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Pressure-induced activation of latent dihydroorotase from Aquifex aeolicus as revealed by high pressure protein crystallography. Febs J., 286, 2019
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8EPW
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![BU of 8epw by Molmil](/molmil-images/mine/8epw) | Crystal Structure of KRAS4b-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) of RAF1/CRAF | Descriptor: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | Deposit date: | 2022-10-06 | Release date: | 2023-06-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Reduced dynamic complexity allows structure elucidation of an excited state of KRAS G13D . Commun Biol, 6, 2023
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