8F5X

Crystal structure of human eosinophil-derived neurotoxin (EDN, ribonuclease 2) in complex with 5'-adenosine monophosphate (AMP)

Summary for 8F5X

Entry DOI	10.2210/pdb8f5x/pdb
Descriptor	Non-secretory ribonuclease, SUCCINIC ACID, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	edn, rnase 2, ribonuclease, eosinophil-derived neurotoxin, transphosphorylase, amp, adenosine monophosphate, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	16561.51
Authors	Tran, T.T.Q.,Pham, N.T.H.,Calmettes, C.,Doucet, N. (deposition date: 2022-11-15, release date: 2023-11-29, Last modification date: 2024-05-29)
Primary citation	Tran, T.T.Q.,Narayanan, C.,Loes, A.N.,Click, T.H.,Pham, N.T.H.,Letourneau, M.,Harms, M.J.,Calmettes, C.,Agarwal, P.K.,Doucet, N. Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases. J.Biol.Chem., 300:107280-107280, 2024 Cited by PubMed: 38588810 DOI: 10.1016/j.jbc.2024.107280 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation