3KXU

Crystal structure of human ferritin FTL498InsTC pathogenic mutant

Summary for 3KXU

DescriptorFerritin, CADMIUM ION, SULFATE ION, ... (4 entities in total)
Functional Keywordsiron storage protein, disorder, iron, metal binding protein
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight22770.08
Authors
Granier, T.,Gallois, B.,Langlois d'Estaintot, B.,Arosio, P. (deposition date: 2009-12-04, release date: 2010-02-09, Last modification date: 2011-07-13)
Primary citation
Luscieti, S.,Santambrogio, P.,Langlois d'Estaintot, B.,Granier, T.,Cozzi, A.,Poli, M.,Gallois, B.,Finazzi, D.,Cattaneo, A.,Levi, S.,Arosio, P.
Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation.
J.Biol.Chem., 285:11948-11957, 2010
PubMed: 20159981 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M109.096404
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2182004.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 3kxu
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Molmil generated image of 3kxu
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Molmil generated image of 3kxu
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3kxu.pdb1.gz [716.51 KB])