3KXU
Crystal structure of human ferritin FTL498InsTC pathogenic mutant
Summary for 3KXU
Entry DOI | 10.2210/pdb3kxu/pdb |
Descriptor | Ferritin, CADMIUM ION, SULFATE ION, ... (4 entities in total) |
Functional Keywords | iron storage protein, disorder, iron, metal binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 22770.08 |
Authors | Granier, T.,Gallois, B.,Langlois d'Estaintot, B.,Arosio, P. (deposition date: 2009-12-04, release date: 2010-02-09, Last modification date: 2023-11-01) |
Primary citation | Luscieti, S.,Santambrogio, P.,Langlois d'Estaintot, B.,Granier, T.,Cozzi, A.,Poli, M.,Gallois, B.,Finazzi, D.,Cattaneo, A.,Levi, S.,Arosio, P. Mutant ferritin L-chains that cause neurodegeneration act in a dominant-negative manner to reduce ferritin iron incorporation. J.Biol.Chem., 285:11948-11957, 2010 Cited by PubMed: 20159981DOI: 10.1074/jbc.M109.096404 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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