3KXU

Crystal structure of human ferritin FTL498InsTC pathogenic mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0016020	cellular_component	membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0035578	cellular_component	azurophil granule lumen
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0055072	biological_process	obsolete iron ion homeostasis
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 301

Chain	Residue
A	HIS115
A	CYS127
A	HOH192
A	HOH193
A	HOH194
A	HOH215

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 302

Chain	Residue
A	CD304
A	HIS50
A	GLU54
A	HOH220

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CD A 304

Chain	Residue
A	HIS50
A	CD302

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 305

Chain	Residue
A	GLU54
A	GLU57
A	HOH221
A	HOH222
A	HOH223

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 306

Chain	Residue
A	GLU58
A	GLU61
A	HOH224
A	HOH225

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 308

Chain	Residue
A	GLU89
A	HOH226
A	HOH227

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 309

Chain	Residue
A	HIS133
A	HOH228
A	HOH229
A	HOH230
A	HOH231
A	HOH232

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 312

Chain	Residue
A	GLU87
A	HOH233
A	HOH234
A	HOH235

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 313

Chain	Residue
A	CYS127
A	ASP128
A	GLU131
A	GLU131

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CD A 314

Chain	Residue
A	ASP128

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 315

Chain	Residue
A	ASP12
A	ASP12
A	HOH236
A	HOH236
A	HOH237
A	HOH237

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 316

Chain	Residue
A	HIS153
A	HOH238
A	HOH239

---

site_id	BC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 317

Chain	Residue
A	SER10
A	ASP12
A	ARG121
A	ARG121
A	HOH237
A	HOH345
A	HOH346
A	HOH381
A	HOH419
A	HOH423

---

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFLEthFLdeevklIK

Chain	Residue	Details
A	ASP123-LYS143

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EkREgyERLLkmQNqRgGR

Chain	Residue	Details
A	GLU58-ARG76

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"Catalytic site for iron oxidation"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"6653779","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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